Title:Recent Progress of Marine Polypeptides as Anticancer Agents
Volume: 13
Issue: 4
Author(s): Lanhong Zheng, Yixin Xu, Xiukun Lin*, Zhixin Yuan, Minghua Liu, Shousong Cao, Fuming Zhang and Robert J. Linhardt
Affiliation:
- Department of Pharmacology, Southwest Medical University, Luzhou, Sichuan, 646000,China
Keywords:
Anticancer, apoptosis, angiogenesis, marine organisms, peptides/polypeptides, tubulin-microtubule equilibrium.
Abstract: Background: Marine environment constitutes an almost infinite resource for novel anticancer
drug discovery. The biodiversity of marine organisms provides a rich source for the discovery and
development of novel anticancer peptides in the treatment of human cancer. Marine peptides represent
a new opportunity to obtain lead compounds in biomedical field, particularly for cancer therapy.
Objective: Providing an insight of the recent progress of patented marine peptides and presenting information
about the structures and mechanistic mode of anticancer activities of these marine peptides.
Methods: We reviewed recent progress on the patented anticancer peptides from marine organisms
according to their targets on different signal pathways. This work focuses on relevant recent patents
(2010-2018) that entail the anticancer activity with associated mechanism and related molecular diversity
of marine peptides. The related cellular signaling pathways for novel peptides that induce apoptosis
and affect tubulin-microtubule equilibrium, angiogenesis and kinase activity that are related to the
anticancer and related pharmacological properties are also discussed.
Results: The recent patents (2010-2018) of marine peptides with anticancer activity were reviewed,
and the anticancer activity of marine peptides with associated mechanism and related molecular diversity
of marine peptides were also discussed.
Conclusion: Marine peptides possess chemical diversity and display potent anticancer activity via
targeting different signal pathways. Some of the marine peptides are promising to be developed as
novel anticancer agents.
