Abstract
Behavioral studies in animals are an important part of neuropharmacological research, because they integrate findings from in vitro pharmacology, chemical neuroanatomy and electrophysiology at the systems level, thereby bridging the gap between basic research on one hand, and the development of pharmacological treatment with clinical trials on the other hand. Animal behavioral models of neuropsychiatric diseases (such as fear/anxiety disorders, depression, addiction, or schizophrenia) are, therefore, an eminent part of preclinical neuropharmacology. We review here recent neuropharmacological findings on prepulse inhibition (PPI) and fear-potentiation of the startle response (FPS) as behavioral models for sensorimotor gating deficits in neuropsychiatric disorders and fear/anxiety-related disorders, respectively.
Keywords: anxiety, fear, fear-potentiated startle, prepulse inhibition, schizophrenia
Current Neuropharmacology
Title: Startle Response Modulation as a Behavioral Tool in Neuropharmacology
Volume: 1 Issue: 2
Author(s): M. Koch and M. Fendt
Affiliation:
Keywords: anxiety, fear, fear-potentiated startle, prepulse inhibition, schizophrenia
Abstract: Behavioral studies in animals are an important part of neuropharmacological research, because they integrate findings from in vitro pharmacology, chemical neuroanatomy and electrophysiology at the systems level, thereby bridging the gap between basic research on one hand, and the development of pharmacological treatment with clinical trials on the other hand. Animal behavioral models of neuropsychiatric diseases (such as fear/anxiety disorders, depression, addiction, or schizophrenia) are, therefore, an eminent part of preclinical neuropharmacology. We review here recent neuropharmacological findings on prepulse inhibition (PPI) and fear-potentiation of the startle response (FPS) as behavioral models for sensorimotor gating deficits in neuropsychiatric disorders and fear/anxiety-related disorders, respectively.
Export Options
About this article
Cite this article as:
Koch M. and Fendt M., Startle Response Modulation as a Behavioral Tool in Neuropharmacology, Current Neuropharmacology 2003; 1 (2) . https://dx.doi.org/10.2174/1570159033477161
DOI https://dx.doi.org/10.2174/1570159033477161 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract
Current Molecular Pharmacology Neuritin, A Neurotrophic Factor in Nervous System Physiology
Current Medicinal Chemistry Regenerative Medicine in Retina: The Future Cure
Current Tissue Engineering (Discontinued) Targeting of Peripherally Expressed Pain-Related Molecules in Injury- Induced Chronic Neuropathic Pain
CNS & Neurological Disorders - Drug Targets Cognitive Impacts of Estrogen Treatment in Androgen-Deprived Males: What Needs to be Resolved
Current Neuropharmacology Stem Cell Therapy for Alzheimers Disease
CNS & Neurological Disorders - Drug Targets Amyloid β Peptide Levels Increase in Brain of AβPP Swedish Mice after Exposure to Chlorpyrifos
Current Alzheimer Research Overview of Pediatric Epilepsy
Current Pediatric Reviews The Long-Term Impact of Early Adversities on Psychiatric Disorders: Focus on Neuronal Plasticity
Current Pharmaceutical Design Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives
Current Medicinal Chemistry Cannabis and Cognitive Systems in Adolescents
Adolescent Psychiatry An Evolution of Bilirubin Physiology and Analysis
Current Signal Transduction Therapy The Heme Oxygenase/Biliverdin Reductase Pathway in Drug Research and Development
Current Drug Metabolism Role of Neuromodulation and Optogenetic Manipulation in Pain Treatment
Current Neuropharmacology Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs
Current Neuropharmacology Alpha-7 Nicotinic Receptors in Nervous System Disorders: From Function to Therapeutic Perspectives
Central Nervous System Agents in Medicinal Chemistry Current Development in Encapsulated Cell Therapy for Degenerative Retinopathies
Current Tissue Engineering (Discontinued) Nicotine and Nicotinic Receptor Involvement in Neuropsychiatric Disorders
Current Topics in Medicinal Chemistry Cannabis Use and Psychosis: Theme Introduction
Current Pharmaceutical Design Pharmacologic Treatments in “Prodromal Psychosis:” Making Clinical Decisions in the Absence of a Consensus
Adolescent Psychiatry