Title:Coenzyme Q10: A Potential Adjunct for Treatment of Antiphospholipid Syndrome and Recurrent Miscarriage
Volume: 14
Issue: 1
Author(s): Hari Shankar*, Priyanka Verma and Donthamsetty Nageswara Rao*
Affiliation:
- Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029,India
- Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029,India
Keywords:
Antiphospholipid syndrome, Coenzyme Q10, endothelial dysfunction, oxidative stress, recurrent miscarriage, gestation.
Abstract: Background: Recurrent Miscarriage (RM) is one of the most frustrating clinical situations
wherein most of the cases, neither the engaged obstetrician nor suffering couples know the exact
etiology and cause of the disease. About 10-15% of women with RM diagnosed with
antiphospholipid syndrome (APS) are characterized by the marked presence of antiphospholipid
antibodies (aPLa). There are several scientific reports available on the association between APS and
RM; however, scanty data available about the beneficial role of coenzyme Q10 (CoQ10) in APS and
APS mediated RM. In the present attempt, we tried to gather information to explain the possible
associations between the role of CoQ10 in RM and APS.
Methods: We collected peer-reviewed literature using keywords; antiphospholipid syndrome, CoQ10,
endothelial dysfunction, oxidative stress and recurrent miscarriage in online electronic databases,
such as Web of Science, Science Direct, Google Scholar, PubMed and Medline. The qualitative
analysis of content was done by summarizing interventions and findings of included studies, on the
basis of which a conceptual framework was prepared for this narrative review.
Results: The beneficial role of CoQ10 in diverse pathological conditions has been summarized and the
evidence suggests that CoQ10 being a potent antioxidant helps in the amelioration of free radicalmediated
aPLa production, endothelial damage and mitochondrial dysfunction. The supplementation
of CoQ10 overcomes the immune dysregulation in idiopathic RM and APS; thus could be a possible
therapeutic adjunct in such diseases.
Conclusion: Based on this review, further comprehensive studies may be conducted to illuminate the
beneficial therapeutic effects of supplementing CoQ10 on possible modifiable pathways involved in
the progression of RM and APS.
