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摘要
醛固酮是主要的矿物质皮质激素,在调节电解质稳态和血压方面起着至关重要的作用。虽然这个角色无疑很重要,但它不是荷尔蒙。最吸引人注意的行动。醛固酮在心血管疾病(CVD)的病理过程中起着重要的局部信使作用。在过去的几年里,人们的注意力集中在D关于醛固酮水平升高与心血管事件风险增加之间的关系。已证实醛固酮可导致纤维化、炎症、内皮功能障碍。离子、纤溶紊乱和氧化应激导致CVD的发展和进展。过去人们认为醛固酮的作用是通过经典的核受体矿物介导的。皮质激素受体(MRS)。现在我们知道醛固酮在心血管系统(Cvs)中的作用机制要复杂得多,因为实验和临床研究表明blocka先生。De可能不足以消除醛固酮对CVS的有害影响。因此,除了MR受体和其他因素外,还有其他因素的参与。此外,除了一般的已知醛固酮的基因组作用,涉及MR激活,非基因组途径被假定为激素作用模式。膜耦合研究越来越受到人们的重视。它介导醛固酮的快速作用,并已在CVS的不同细胞和组织中得到证实。因此,这个简短的回顾总结了最近关于新的方面的发现。醛固酮在CVS中的作用可能是治疗干预的潜在靶点。
关键词: 醛固酮、基因组、非基因组、矿物皮质激素受体、糖皮质激素受体、血管紧张素Ⅱ受体1型、G蛋白偶联雌激素受体。
Current Drug Targets
Title:New Sides of Aldosterone Action in Cardiovascular System as Potential Targets for Therapeutic Intervention
Volume: 19 Issue: 16
关键词: 醛固酮、基因组、非基因组、矿物皮质激素受体、糖皮质激素受体、血管紧张素Ⅱ受体1型、G蛋白偶联雌激素受体。
摘要: Aldosterone, the main mineralocorticoid hormone, plays a crucial role in the regulation of electrolyte homeostasis and blood pressure. Although this role is undoubtedly important, it is not a hormonal action that attracts the most attention. Aldosterone seems to be very important as a local messenger in the pathology of cardiovascular diseases (CVD). In the last few years, the attention was focused on the correlation between raised aldosterone level and increased risk of cardiovascular events. It has been demonstrated that aldosterone contributes to fibrosis, inflammation, endothelial dysfunction, fibrinolytic disorders, and oxidative stress leading to CVD development and progression. It used to be thought that the effects of aldosterone are mediated via classic nuclear receptors – mineralocorticoid receptors (MRs). Now we know that the mechanism of aldosterone action in the cardiovascular system (CVS) is much more complex since experimental and clinical studies indicate that MR blockade may be not sufficient to abolish aldosterone-induced harmful effects in CVS. Thus, the involvement of some other than MR, receptors, and factors is suggested. Moreover, in addition to the generally known genomic action of aldosterone, which involves MR activation, the nongenomic pathways are postulated in the mode of hormone action. More and more attention is focused on the membrane-coupled receptors, which mediate the rapid effects of aldosterone and have been already confirmed in different cells and tissues of CVS. Therefore, this brief review summarizes recent findings about new sides of aldosterone action in CVS that could be potential targets for therapeutic intervention.
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Cite this article as:
New Sides of Aldosterone Action in Cardiovascular System as Potential Targets for Therapeutic Intervention, Current Drug Targets 2018; 19 (16) . https://dx.doi.org/10.2174/1389450119666180326125926
DOI https://dx.doi.org/10.2174/1389450119666180326125926 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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