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Review Article

PI3K信号在慢性阻塞性肺疾病：机制，目标和治疗

卷 26, 期 16, 2019

页: [2791 - 2800] 页: 10

弟呕挨: 10.2174/0929867325666180320120054

价格: $65

摘要

慢性阻塞性肺病（COPD）是一种进行性呼吸系统疾病，其特征在于不可逆的慢性炎症和气流阻塞。 它影响到全世界超过6400万患者，预计到2030年它将成为工业化国家的第三大死因。目前可用的治疗方法无法阻止疾病进展和降低死亡率，因此需要更好地了解COPD 确定新的分子治疗靶点的病理生理机制。 最近的研究表明，磷酸肌醇3-激酶（PI3K）信号在COPD中显着激活，并与患者对肺部感染的易感性增加相关。 因此，PI3K已成为COPD的有希望的替代药物靶标，并且已经在临床前模型中测试了多种泛同种型和同种型选择性抑制剂，并且目前正在临床研究中进行评估。 在这里，我们总结了最近关于PI3K酶参与COPD病理生理学的知识，并且我们讨论了PI3K抑制剂作为COPD新疗法的临床前和临床测试所产生的最新结果。

关键词: COPD，PI3K，炎症，靶向治疗，临床试验，P13K抑制剂。

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