Abstract
Background: A close relationship between rheumatic diseases and cardiovascular disease (CVD) has been reported, accounting for the higher mortality and morbidity observed in these patients. In the last years, it has been clearly reported that patients affected by primary Sjögren’s syndrome (pSS) experienced an increased risk of CVD.
Objective: This review aimed at investigating CVD, traditional cardiovascular (CV) risk factors and possible targeted therapeutic strategies in pSS patients.
Method: Available literature concerning CV risk factors in pSS patients has been selected and discussed.
Conclusion: Disease-related characteristics and traditional CV risk factors contribute to observed atherosclerotic damage in pSS patients. The pro-inflammatory mediators together with hypertension and type 2 diabetes, which are more prevalent in pSS patients, determine the increased CV burden. Future studies are needed to fully elucidate the role of possible targeted therapies.
Keywords: Atherosclerosis, cardiovascular disease, cardiovascular risk, comorbidity, endothelial damage, Sjögren syndrome.
Reviews on Recent Clinical Trials
Title:Cardiovascular Disease in Primary Sjögren’s Syndrome
Volume: 13 Issue: 3
Author(s): Onorina Berardicurti*, Piero Ruscitti, Paola Cipriani, Francesco Ciccia, Vasiliki Liakouli, Giuliana Guggino, Francesco Carubbi, Paola Di Benedetto, Giovanni Triolo and Roberto Giacomelli
Affiliation:
- Division of Rheumatology, University of L`Aquila, L`Aquila,Italy
Keywords: Atherosclerosis, cardiovascular disease, cardiovascular risk, comorbidity, endothelial damage, Sjögren syndrome.
Abstract: Background: A close relationship between rheumatic diseases and cardiovascular disease (CVD) has been reported, accounting for the higher mortality and morbidity observed in these patients. In the last years, it has been clearly reported that patients affected by primary Sjögren’s syndrome (pSS) experienced an increased risk of CVD.
Objective: This review aimed at investigating CVD, traditional cardiovascular (CV) risk factors and possible targeted therapeutic strategies in pSS patients.
Method: Available literature concerning CV risk factors in pSS patients has been selected and discussed.
Conclusion: Disease-related characteristics and traditional CV risk factors contribute to observed atherosclerotic damage in pSS patients. The pro-inflammatory mediators together with hypertension and type 2 diabetes, which are more prevalent in pSS patients, determine the increased CV burden. Future studies are needed to fully elucidate the role of possible targeted therapies.
Export Options
About this article
Cite this article as:
Berardicurti Onorina*, Ruscitti Piero, Cipriani Paola, Ciccia Francesco, Liakouli Vasiliki, Guggino Giuliana, Carubbi Francesco, Di Benedetto Paola, Triolo Giovanni and Giacomelli Roberto, Cardiovascular Disease in Primary Sjögren’s Syndrome, Reviews on Recent Clinical Trials 2018; 13 (3) . https://dx.doi.org/10.2174/1574887113666180315130336
DOI https://dx.doi.org/10.2174/1574887113666180315130336 |
Print ISSN 1574-8871 |
Publisher Name Bentham Science Publisher |
Online ISSN 1876-1038 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Lipoprotein(a) Management: Pharmacological and Apheretic Treatment
Current Medicinal Chemistry Potential of Resveratrol in Preventing the Development of Heart Failure
Current Chemical Biology Emerging Risk Factors for Dementia: The Role of Blood Pressure Variability
CNS & Neurological Disorders - Drug Targets The Pathophysiology of Heart Failure in Children: The Basics
Current Cardiology Reviews C-Reactive Protein and Hypertension: Is there A Causal Relationship?
Current Pharmaceutical Design Impact of Patient Knowledge of Hypertension Complications on Adherence to Antihypertensive Therapy
Current Hypertension Reviews The Renin-Angiotensin Systems: Evolving Pharmacological Perspectives for Cerebroprotection
Current Pharmaceutical Design Duloxetine in the Treatment of Depression: An Overview
Central Nervous System Agents in Medicinal Chemistry Interaction of the Heart and Lungs During Exercise: Physiology and Pathophysiology in Children with Congenital Heart Disease
Current Respiratory Medicine Reviews Mineralocorticoid Receptor Antagonists in Cardiovascular Medicine: Looking for the Forest Among the Trees
Current Pharmaceutical Design Menopause and its Cardiometabolic Consequences: Current Perspectives
Current Vascular Pharmacology Applications of Muscle Electroporation Gene Therapy
Current Gene Therapy Patent Review
Combinatorial Chemistry & High Throughput Screening Lifestyle Modification for Masked Hypertension
Current Hypertension Reviews Opportunities and Challenges for Host-Directed Therapies in Tuberculosis
Current Pharmaceutical Design Formulation, Characterization and In Vivo Evaluation of Self-Nanoemulsifying Drug Delivery System for Oral Delivery of Valsartan
Current Nanoscience Mitochondrial Dysfunction, Oxidative Stress and Diabetic Cardiovascular Disorders
Cardiovascular & Hematological Disorders-Drug Targets Cyclooxygenase-2 and Prostaglandin E2 are Associated with Middle Cerebral Artery Occlusion and Hemorrhage in Patients with Moyamoya Disease
Current Neurovascular Research Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Disease
Current Pharmaceutical Design Oxidative Stress in Diabetic Nephropathy
Current Medicinal Chemistry