摘要
适度运动训练是一级和二级预防策略的一个关键方面。剪切诱导血管内皮细胞eNOS活性和功能的上调是运动对心肌缺血/再灌注损伤(I/R)保护作用的主要分子机制之一。据报道,急性运动后正常人血浆亚硝酸盐水平明显升高,而冠心病患者血浆亚硝酸根水平明显升高。本研究小组和其他研究表明,RBCs含有功能性eNOS,这有助于系统亚硝酸盐稳态和心脏保护;此外,红细胞eNOS在CAD患者中的表达和活性降低,并与血流介导的舒张功能(内皮功能的诊断指标)显著相关。因此,除血管eNOS外,红细胞eNOS(或更一般意义上说,RBCs不具有代谢活性)也可能在运动依赖的NO生物利用度变化中发挥作用。在这篇综述中,我们将重点关注RBCs在运动依赖性心脏保护中的作用,重点是红细胞信号和红细胞eNOS。详细地,我们将讨论剪应力和运动训练对红细胞信号和功能的影响和分子机制,综述这些变化如何影响血液流变学和全身血流动力学,并强调红细胞eNOS介导的心血管保护在动物和人类研究和临床环境中对心肌损伤的潜在作用。
关键词: eNOS,红细胞,剪应力,运动,缺血/再灌注,心肌梗死,心脏保护。
Current Medicinal Chemistry
Title:Exercise-Induced Cardioprotection via eNOS: A Putative Role of Red Blood Cell Signaling
Volume: 25 Issue: 34
关键词: eNOS,红细胞,剪应力,运动,缺血/再灌注,心肌梗死,心脏保护。
摘要: Moderate exercise training is a key aspect of primary and secondary prevention strategies. Shear-induced upregulation of eNOS activity and function in the vascular endothelium is considered as one of the main molecular mechanisms of exercise-induced protection against myocardial ischemia/ reperfusion (I/R) injury. It has been reported that levels of plasma nitrite, which are largely dependent on eNOS activity, were increased in healthy subjects after acute exercise, while this increase was abolished in coronary artery disease (CAD) patients. Our group and others demonstrated that RBCs contain a functional eNOS, which contributes to systemic nitrite homeostasis and to cardioprotection; moreover, expression and activity of red cell eNOS are decreased in CAD patients and significantly correlated with flow-mediated dilation, a diagnostic marker of endothelial function. Therefore, in addition to vascular eNOS, also red cell eNOS (or in more general terms NO metabolic activity of RBCs) may play a role in exercise-dependent changes of NO-bioavailability. In this review, we will focus on what is known and what is unknown about the role of RBCs in exercise-dependent cardioprotection with emphasis on RBC signaling and red cell eNOS. In detail, we will discuss the effects and molecular mechanisms of shear stress and exercise training on RBC signaling and function, review how these changes may influence blood rheology and systemic hemodynamics and highlight the potential role of red cell eNOS-mediated cardiovascular protection induced by physical activity against myocardial injury in animal and human studies and in clinical settings.
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Exercise-Induced Cardioprotection via eNOS: A Putative Role of Red Blood Cell Signaling, Current Medicinal Chemistry 2018; 25 (34) . https://dx.doi.org/10.2174/0929867325666180307112557
DOI https://dx.doi.org/10.2174/0929867325666180307112557 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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