Title:Frontier View on Nanotechnological Strategies for Neuro-therapy
Volume: 19
Issue: 7
Author(s): Asim Azhar, Ghulam Md. Ashraf*, Qamar Zia, Shakeel A. Ansari, Asma Perveen, Abdul Hafeez, Mohd Saeed, Mohammad A. Kamal, Athanasios Alexiou, Magdah Ganash, Nagendra S. Yarla, Saleh S. Baeesa, Mohamed M. Alfiky and Osama S. Bajouh
Affiliation:
- King Fahd Medical Research Center, King Abdulaziz University, Jeddah,Saudi Arabia
Keywords:
Alzheimer's disease, blood brain barrier, drug delivery, nanotechnology, nanotechnology based approaches, neurological disorders.
Abstract: Background: Nanotechnology exploits materials and devices with a functional organization that has been
engineered at the nanometre scale. The application of nanotechnology in neuroscience involves specific interactions
with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes,
oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering
the drug successfully to the brain.
Objective: Nanotechnology based approaches (NBA) favours transcytosis-mediated delivery of nanoparticles to the
brain by crossing the BBB. The last five years have witnessed the successful applications of NBA to treat neurological
disorders. It is expected that the development of novel NBA will result in important insights on the brain mechanisms,
and eventually provide better medical care to patients suffering from neurological disorders.
Conclusion: This review introduces the emerging work in this area and summarizes the successful NBA used in
recent past for treating various neurological disorders ike Alzheimer’s disease, Parkinson's disease, amyotrophic
lateral sclerosis, meningitis and glioblastoma.
