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Review Article

G-四链体在线粒体中的潜在作用

卷 26, 期 16, 2019

页: [2918 - 2932] 页: 15

弟呕挨: 10.2174/0929867325666180228165527

价格: $65

摘要

富含鸟嘌呤（G）核苷酸的一些DNA或RNA序列可采用称为G-四链体（G4）的非常规构象。 在核基因组中，G4基序与基因组不稳定性和基因表达缺陷有关，但它们越来越被认为是调节结构。 最近的研究表明，G4结构可以在线粒体基因组（mtDNA）中形成，潜在的G4形成序列与mtDNA缺失的起源有关。 然而，关于G4结构在线粒体中的调节作用知之甚少。 在这篇简短的综述中，我们将根据来自细胞核的证据，探索G4结构调节线粒体功能的可能性。

关键词: G-四链体，mtDNA，线粒体基因表达，线粒体基因组不稳定性，mtDNA缺失，mtDNA消耗，G4配体。

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