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Review Article

DNA双链断裂修复抑制剂：相关性作为潜在的新抗癌治疗药物

卷 26, 期 8, 2019

页: [1483 - 1493] 页: 11

弟呕挨: 10.2174/0929867325666180214113154

价格: $65

摘要

DNA双链断裂被认为是最致命的DNA损伤形式之一。许多有效的抗癌治疗方法使用化学和物理方法在癌细胞中产生DNA双链断裂。它们包括：IR和模拟其作用的药物，拓扑异构酶毒物，一些烷化剂或影响DNA复制过程的药物。另一方面，癌细胞的特征主要在于高效的DNA损伤修复系统。有两种主要的DNA修复途径用于修复双链断裂：NHEJ和HRR。他们的活动导致化疗效果下降。直接或间接靶向DNA双链断裂抑制剂的反应似乎是抗癌治疗的令人兴奋的选择，并且是PARP抑制剂临床成功后出现的新趋势的一部分。这些趋势将为DNA修复抑制剂的开发提供巨大的机会，作为新的潜在抗癌药物。本文的主要目的是解决这些新的有希望的进展。

关键词: 双链断裂修复，DNA双链断裂，同源重组，非同源末端连接，抗癌疗法，抑制剂。

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