摘要
脑实质内出现的β-淀粉样蛋白(Aβ)斑块已被广泛证明是阿尔茨海默病(AD)的标志之一。根据淀粉样蛋白级联假说,Aβ斑块在脑内的蓄积是疾病发生的内在和根本原因,而AD的早期诊断则是基于此而进行的大量研究。Aβ检测的最新进展集中于使用精细、无创、廉价的光学成像技术对脑内分子事件的映射,这刺激了β-特异性荧光探针的快速发展。其中,近红外(NIR)荧光团由于组织中微弱的光衰减和避免生物物质的自动荧光而收获了足够的关注。在这篇综述中,我们展示了在体外或体内检测脑内Aβ斑块的荧光探针的最新发展,并重点介绍了用于体内双光显微术和近红外成像的探针,通过突出它们的生物和光化学探针。
关键词: 阿尔茨海默病、β淀粉样斑块、光学成像、荧光探针、小分子、近红外。
Current Medicinal Chemistry
Title:Fluorescent Imaging of Amyloid-β Deposits in Brain: An Overview of Probe Development and a Highlight of the Applications for In Vivo Imaging
Volume: 25 Issue: 23
关键词: 阿尔茨海默病、β淀粉样斑块、光学成像、荧光探针、小分子、近红外。
摘要: The β-amyloid (Aβ) plaques presented within the brain parenchyma have been widely proved to be one of the hallmarks of Alzheimer’s disease (AD). According to the amyloid cascade hypothesis, the accumulation of Aβ plaques in the brain is intrinsic and fundamental for disease onset, and much research about the early diagnosis of AD is based on this. A recent development in Aβ detection has focused on the mapping of the molecule events in the brain using an exquisite, noninvasive, and inexpensive optical imaging technique, which has stimulated the rapid development of Aβ-specific fluorescent probes. Among them, nearinfrared (NIR) fluorophores have gained adequate attention due to the weak light attenuation in tissues and avoidance from auto-fluorescence of biological matter. In this review, we showcase the current developments of fluorescent probes that are subject to in vitro or in vivo detection of Aβ plaques in the brain, and give an emphasis on the probes used for in vivo twophoton microscopy and NIR imaging by highlighting their biological and photochemical properties.
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Cite this article as:
Fluorescent Imaging of Amyloid-β Deposits in Brain: An Overview of Probe Development and a Highlight of the Applications for In Vivo Imaging, Current Medicinal Chemistry 2018; 25 (23) . https://dx.doi.org/10.2174/0929867325666180214110024
DOI https://dx.doi.org/10.2174/0929867325666180214110024 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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