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General Review Article

神经节苷脂GM3及其在癌症中的作用

卷 26, 期 16, 2019

页: [2933 - 2947] 页: 15

弟呕挨: 10.2174/0929867325666180129100619

价格: $65

摘要

神经节苷脂GM3与人类肿瘤，如肺癌，脑癌和黑色素瘤密切相关，越来越多的证据表明GM3对癌症的发展和进展具有强大的作用。 GM3在几种类型的癌症中过度表达，并且可以作为肿瘤相关的碳水化合物抗原，用于癌症的免疫疗法。 GM3还可通过抗血管生成或运动等抑制肿瘤细胞的生长。 特别是，GM3对EGFR酪氨酸激酶信号传导，uPAR相关信号传导和富含糖脂的微区有影响，这些微区是癌症信号传导所必需的。 很明显，GM3将成为癌症治疗的有希望的目标。

关键词: GM3，抗肿瘤，免疫疗法，EGFR，uPAR相关信号传导，抗血管生成，细胞运动，富含GM3的微区。

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