摘要
CD 73又称ecto-5‘-核苷酸酶(En,NT5E,EC3.13.5),是一种抑制腺苷生成的酶,在多种细胞上均有表达。它的表达受到Hyp的显著影响。氧和炎症因子。在炎症过程中,CD 73保护内皮屏障功能,抑制白细胞的迁移。CD 73还促进M2巨噬细胞(抗炎表型)。在.CD 73在Treg细胞上表达,通过腺苷介导免疫抑制。CD 73是免疫和炎症的重要调节因子。它的表达与多个d有关。疾病,如自身免疫性疾病,缺血再灌注损伤,动脉钙化和动脉粥样硬化。CD 73在许多癌症中过度表达。它的表达与t呈正相关。UMOR生长、转移、血管生成、预后差及对化疗的耐药性。因此,CD 73可作为癌症等疾病的预后指标和治疗靶点。
关键词: CD 73,外显子-5‘-核苷酸酶,癌症,免疫,炎症,疾病。
Current Medicinal Chemistry
Title:Role of CD73 in Disease: Promising Prognostic Indicator and Therapeutic Target
Volume: 25 Issue: 19
关键词: CD 73,外显子-5‘-核苷酸酶,癌症,免疫,炎症,疾病。
摘要: CD73, also known as ecto-5’-nucleotidase (eN, NT5E, EC3.13.5), is the ratelimiting enzyme for adenosine generation and is expressed on multiple cells. Its expression is significantly influenced by hypoxia and inflammatory factors. During inflammation, CD73 protects endothelial barrier function and inhibits leukocyte trafficking. CD73 also promotes M2 macrophages (anti-inflammatory phenotype). In addition, CD73 is expressed on Treg cells and mediates immune suppression through adenosine. CD73 serves as an essential regulator for the immunity and inflammation. Its expression is related to many diseases, such as autoimmune diseases, ischemia-reperfusion injuries, arterial calcifications, and atherosclerosis. CD73 is overexpressed in many cancers. Its expression is positively associated with tumor growth, metastasis, angiogenesis, poor prognosis and resistance to chemotherapy. Thus, CD73 may be used for prognostic indicator and therapeutic target in diseases such as cancers.
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Role of CD73 in Disease: Promising Prognostic Indicator and Therapeutic Target, Current Medicinal Chemistry 2018; 25 (19) . https://dx.doi.org/10.2174/0929867325666180117101114
DOI https://dx.doi.org/10.2174/0929867325666180117101114 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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