摘要
背景:自发性脑出血(ICH)是一种比较常见的致死性疾病,总的全球发病率估计为每100000人24.6年。考虑到MOR的高度与ICH相关的发病率和死亡率,可能具有神经保护作用的疗法,越来越引起临床医生的兴趣。在最后一种情况下,细胞疗法提供了改善的希望。现有治疗方法无法充分解决的疾病过程。 目的:探讨间充质干细胞(MSCs)对脑出血的保护作用及其分子机制。我们还讨论了可能出现的情况。治疗方法值得进一步研究。 方法与结果:现有文献表明,MSCs在ICH动物模型中的治疗潜力明显增强了功能恢复,减少了脑梗死体积。RCT大小发挥抗炎和血管生成的作用。然而,研究干细胞治疗在脑出血动物模型中的疗效的原始文章的质量仍然很差。e缺乏ICH临床试验不允许得出任何相关结论。 结论:尚需进一步研究,才能实现骨髓间充质干细胞分离、鉴定和给药的标准化方法,以改进骨髓间充质干细胞或来源于骨髓间充质干细胞的脑出血治疗conducts举止( conduct的名词复数 )
关键词: 血管生成,抗炎特性,脑出血卒中,细胞外小泡,间充质,干细胞,神经保护作用,脑卒中。
Current Medicinal Chemistry
Title:Mesenchymal Stem Cell Therapy in Intracerebral Haemorrhagic Stroke
Volume: 25 Issue: 19
关键词: 血管生成,抗炎特性,脑出血卒中,细胞外小泡,间充质,干细胞,神经保护作用,脑卒中。
摘要: Background: Spontaneous intracerebral haemorrhage (ICH) is a relatively common fatal disease, with an overall global incidence estimated at 24.6 per 100,000 person- years. Given the high degree of morbidity and mortality associated with ICH, therapies that may have neuroprotective effects are of increasing interest to clinicians. In this last context, cell therapies offer the promise of improving the disease course which cannot be addressed adequately by existing treatments.
Objective: The aim of this review is to evaluate the protective effects and molecular mechanisms of mesenchymal stem cells (MSCs) on haemorrhagic brain following ICH. We also discuss possible emerging therapeutic approaches worth of further research.
Methods and Results: The available literature on the therapeutic potential of MSCs in ICH animal models clearly demonstrated that MSCs enhance the functional recovery and reduce the volume of the infarct size exerting anti-inflammatory and angiogenic properties. However, the quality of the original articles investigating the efficacy of stem cell therapies in ICH animal models is still poor and the lack of ICH clinical trial does not permit to reach any relevant conclusions.
Conclusion: Further studies have to be implemented in order to achieve standardized methods of MSCs isolation, characterization and administration to improve ICH treatments with MSCs or MSC-derived products.
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Cite this article as:
Mesenchymal Stem Cell Therapy in Intracerebral Haemorrhagic Stroke, Current Medicinal Chemistry 2018; 25 (19) . https://dx.doi.org/10.2174/0929867325666180111101410
DOI https://dx.doi.org/10.2174/0929867325666180111101410 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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