摘要
用于癌症化疗的常规药物具有严重的毒副作用并显示出各自不同的治疗反应。纳米技术,生物学,材料科学和药学的融合为癌症化疗提供了一个新策略。装载有抗癌药物的纳米粒子已经被设计用于克服于常规药物限制,几种纳米药物已经被FDA批准并且在临床实践中显示出良好的性能。但是,治疗功效不能提高。考虑到这一点,对刺激敏感的纳米粒子具有提高治疗效果和减少副作用的能力。在这篇综述中,我们系统地总结了基于不同刺激反应(包括pH,温度,光照,氧化还原等)的纳米粒控制抗癌药物释放系统的最新进展。如果过去的成就可以外推到未来,那么很可能最终开发出具有多种期望特性的响应性纳米颗粒用于安全和有效的癌症治疗。
关键词: 纳米颗粒,刺激响应,药物释放,抗癌,化学疗法,生物利用度,增强的渗透和保留(EPR)。
Current Medicinal Chemistry
Title:Stimuli Responsive Nanoparticles for Controlled Anti-cancer Drug Release
Volume: 25 Issue: 16
关键词: 纳米颗粒,刺激响应,药物释放,抗癌,化学疗法,生物利用度,增强的渗透和保留(EPR)。
摘要: Conventional drugs used for cancer chemotherapy have severe toxic side effects and show individually varied therapeutic responses. The convergence of nanotechnology, biology, material science and pharmacy offers a perspective strategy for cancer chemotherapy. Nanoparticles loaded with anti-cancer drug have been designed to overcome the limitations associated with conventional drugs, several nanomedicines have been approved by FDA and shown good performances in clinical practice. However, the therapeutic efficacies cannot be enhanced. Taking this into account, stimuli responsive nanoparticles present the ability to enhance therapeutic efficacy and reduce side effects. In this review, we systematically summarized the recent progresses of controlled anti-cancer drug release systems based on nanoparticles with different stimuli response including pH, temperature, light, redox and others. If the achievements of the past can be extrapolated into the future, it is highly likely that responsive nanoparticles with a wide array of desirable properties can be eventually developed for safe and efficient cancer therapy.
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Stimuli Responsive Nanoparticles for Controlled Anti-cancer Drug Release, Current Medicinal Chemistry 2018; 25 (16) . https://dx.doi.org/10.2174/0929867325666180111095913
DOI https://dx.doi.org/10.2174/0929867325666180111095913 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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