Title:Fenofibrate and Telmisartan in the Management of Abdominal Aortic Aneurysm
Volume: 19
Issue: 11
关键词:
腹主动脉瘤，替米沙坦，非诺贝特，骨桥蛋白，血管紧张素，临床试验。
摘要: Objective: This mini-review provides the rationale and updated progress for ongoing randomized
controlled trials assessing fenofibrate and telmisartan efficacy to limit abdominal aortic aneurysm
(AAA) growth.
Methods/Results: There remains an urgent need to identify a drug therapy that will limit AAA growth.
Data from preclinical and human studies indicate that fenofibrate and telmisartan have the potential to
slow aortic destruction. Fenofibrate has been shown to reduce serum and tissue levels of the proinflammatory
protein osteopontin, as well as reducing macrophage recruitment to the aortic wall, both of
which are integral processes in the development and progression of AAAs. Telmisartan acts via blockade
of the angiotensin II receptor, type 1, and also as a peroxisome proliferator-activated receptor gamma
agonist. In turn, this inhibits the production of a range of biomarkers associated with AAA progression,
including transforming growth factor-beta one, osteoprotegerin, osteopontin and matrix metalloproteinase-
9. Based on these findings, there are currently three randomized controlled trials assessing both fenofibrate
and telmisartan as potential interventions to limit aneurysm growth in AAA patients.
Conclusion: Fenofibrate and telmisartan have potential as repurposed medications to limit AAA
growth, and randomized trials for further assessment in AAA patients are ongoing.
