Title:Therapeutic Applications of Prostaglandins and Thromboxane A2 Inhibitors in Abdominal Aortic Aneurysms
Volume: 19
Issue: 11
关键词:
腹主动脉瘤、前列腺素、血栓素A2、乙酰水杨酸、血小板、环氧合酶。
摘要: Background: Abdominal aortic aneurysm (AAA) is one of the leading causes of death in
western countries. Surgery is still, at the present time, the sole treatment that has however a significant
mortality and cost rate. Many pharmacological agents are under investigation aiming to reduce growth
and prevent AAA rupture. These drugs target different pathological pathways and, notably, the excessive
production of prostanoids by cyclooxygenases (COX). Intra-aneurysmal thrombus plays an adverse
key role in the progression of AAA, platelets being a primary source of prostanoids as thromboxane
A2.
Objective: In this review, we summarize studies targeting prostanoids production and down-stream
pathways in cardiovascular diseases, and more specifically in AAA.
Results and Conclusion: Various inhibitors of COX or antagonists of prostanoids receptors have been
investigated in AAA animal models with conflicting results. In human AAA, only a few number of
studies focused on anti-platelet therapy mostly using acetylsalicylic acid (aspirin, ASA), a COX1 inhibitor.
Finally, we report preliminary promising results of a model of AAA in rats receiving a thromboxane
A2 inhibitor, BM-573 that induced a reduction of aneurysmal growth.
