摘要
基质金属蛋白酶(MMPs)是含有钙依赖性锌的内肽酶的成员,其在细胞外基质(ECM)重塑中起关键作用。也已知MMP切割非基质蛋白,包括细胞表面受体,TNF-α,血管紧张素-II,生长因子(特别是转化生长因子-β1,TGF-β1)纤溶酶原,内皮素和其他生物活性分子。金属蛋白酶组织抑制剂(TIMPs)抑制MMPs的活性并降低ECM降解。各种病理生理条件与ECM合成和降解的不平衡有关。许多研究报道了MMPs和TIMPs在肾病进展中的重要性,包括肾小球肾炎,糖尿病性肾病,肾癌和肾结石。虽然MMPs活性失调可直接或间接导致病理性疾病,但它们在疾病进展中的贡献仍低估。具体而言,肾脏中的MMP活性及其与肾脏疾病的关系一直是少数调查的主题。因此,本综述的目的是提供MMPs和TIMPs参与炎症和退行性肾病发病机制的最新见解。
关键词: 基质金属蛋白酶(MMPs),金属蛋白酶组织抑制剂(TIMPs),肾脏病理学,细胞外基质,纤维化,炎症。
Current Medicinal Chemistry
Title:Role of Matrix Metalloproteinases in Degenerative Kidney Disorders
Volume: 25 Issue: 15
关键词: 基质金属蛋白酶(MMPs),金属蛋白酶组织抑制剂(TIMPs),肾脏病理学,细胞外基质,纤维化,炎症。
摘要: Matrix metalloproteinases (MMPs) are members of calcium dependent-zinc containing endopeptidases that play a pivotal role in extracellular matrix (ECM) remodeling. MMPs are also known to cleave non-matrix proteins, including cell surface receptors, TNF-α, angiotensin-II, growth factors, (especially transforming growth factor-β1, ΤGF- β1) plasminogen, endothelin and other bioactive molecules. The tissue inhibitors of metalloproteinases (TIMPs) inhibit the activity of MMPs and decrease ECM degradation. Various patho-physiological conditions have been linked with the imbalance of ECM synthesis and degradation. Numerous studies have reported the significance of MMPs and TIMPs in the progression of kidney pathologies, including glomerulonephritis, diabetic nephropathy, renal cancer, and nephrolithiasis. Although dysregulated activity of MMPs could directly or indirectly lead to pathological morbidities, their contribution in disease progression is still understated. Specifically, MMP activity in the kidneys and it's relation to kidney diseases has been the subject of a limited number of investigations. Therefore, the aim of the present review is to provide an updated insight of the involvement of MMPs and TIMPs in the pathogenesis of inflammatory and degenerative kidney disorders.
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Cite this article as:
Role of Matrix Metalloproteinases in Degenerative Kidney Disorders, Current Medicinal Chemistry 2018; 25 (15) . https://dx.doi.org/10.2174/0929867325666171205143441
DOI https://dx.doi.org/10.2174/0929867325666171205143441 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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