Title:Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population
Volume: 19
Issue: 5
Author(s): Naseem Akhter, Sajad A. Dar, Shilpi Chattopadhyay, Shafiul Haque, Razique Anwer, Mohd Wahid, Arshad Jawed, Mohtashim Lohani, Raju K. Mandal, N. K. Shukla, Yasir Abdul and Syed Akhtar Husain*
Affiliation:
- Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi- 110025,India
Keywords:
p53 codon72 SNP, Breast cancer, Indian populations, Case-control, Meta-analysis, p53 Arg72Pro polymorphism.
Abstract: Background: Genetic changes in p53 gene contribute to breast cancer susceptibility.
Objective and Methods: A case-control study and a meta-analysis were performed to investigate the
role of p53 codon72 SNP with breast cancer susceptibility in Indian women.
Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total
cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated
with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation
with breast cancer occurrence.
Conclusion: The findings of our case-control study and meta-analysis suggest a significant association
between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.
