Past and Future of Ga-citrate for Infection and Inflammation Imaging

Title:Past and Future of Ga-citrate for Infection and Inflammation Imaging

Volume: 24 Issue: 7

Author(s): Mariza Vorster, John Buscombe*, Ziauddin Saad and Mike Sathekge

Affiliation:

• Department of Nuclear Medicine, University of Pretoria, Steve Biko Academic Hospital, Pretoria,south africa

Keywords: Gallium, infection, inflammation, malignant conditions, 68Ga-citrate, Computed Tomography (CT).

Abstract: Both 67Ga and 68Ga-citrates are used to detect a wide spectrum of pathology consisting of various inflammatory, infectious and malignant conditions. Considering the now widespread availability and constantly increasing demand for PET/CT studies,68Ga-citrate is gaining ground in clinical settings and the added value of combined metabolic and anatomical imaging achieved by combining PET with Computed Tomography (CT) to PET/CT makes 68Ga-citrate particularly promising. Despite the tracer's non-specificity, it has demonstrated potential especially in the evaluation of various infectious and inflammatory skeletal- and lung conditions.

In this review, we will focus on the indications and lessons learned from 67Ga, and present the current status for the use of 68Ga-citrate PET/CT in selected inflammation and infectious diseases based on the limited literature available.

Cite this article as:

Vorster Mariza , Buscombe John*, Saad Ziauddin and Sathekge Mike , Past and Future of Ga-citrate for Infection and Inflammation Imaging, Current Pharmaceutical Design 2018; 24 (7) . https://dx.doi.org/10.2174/1381612824666171129200611