摘要
背景:胆汁酸是胆汁的主要成分之一。最近,它们也被认为是重要的信号分子,不仅通过调节它们自身的合成,而且还发挥作用i。多种代谢性疾病。 目的:研究脱氧胆酸钠(NaDOC)、熊去氧胆酸(UDCA)和利胆酸(LCA)及其组合对肠道Ca2+吸收的影响。制作CL倾听这些BAs在这个生理过程中的作用,概述目前关于肠道Ca2+发生的机制的信息。 方法:检索PubMed数据库至2017年,使用胆汁酸、NaDOC、UDCA、LCA、氧化还原状态、细胞凋亡、自噬和肠钙吸收等关键词。 结果:氧化还原状态的调节、细胞凋亡和自噬是BAS对肠内Ca2+吸收的作用机制。尽管这些机制还没有完全实现最后,我们提供了有关BAS对肠道钙吸收影响的最新知识。 结论:BAS影响肠道对Ca2+的吸收反应,但与BA的类型和剂量有关。当有一个单一的管理,NaDOC有一个抑制的ef。FECT,UDCA是刺激器,而LCA没有任何影响。然而,BAS的组合改变了响应。无论是UDCA还是LCA都能保护肠道免受氧化损伤的影响。D通过阻断氧化/亚硝基应激、凋亡和自噬作用而被NaDOC所阻断。
关键词: 胆汁酸、肠钙吸收、NaDOC、UDCA、LCA、氧化应激、自噬、亚硝化应激、凋亡。
Current Medicinal Chemistry
Title:Molecular Mechanisms Triggered by Bile Acids on Intestinal Ca2+ Absorption
Volume: 25 Issue: 18
关键词: 胆汁酸、肠钙吸收、NaDOC、UDCA、LCA、氧化应激、自噬、亚硝化应激、凋亡。
摘要: Background: Bile acids (BAs) are among the main components of bile. Lately, they are also considered important signaling molecules, not only by regulating their own synthesis, but also having a role in several metabolic diseases.
Objective: In this review we focus on the effect of sodium deoxycholate (NaDOC), ursodeoxycholic (UDCA) and litocholic (LCA) acids and their combination upon the intestinal Ca2+ absorption. To make clear the actions of those BAs on this physiological process, an overview of current information about the mechanisms by which the intestinal Ca2+ occurs is described.
Methods: The PubMed database was searched until 2017, using the keywords bile acids, NaDOC, UDCA and LCA and redox state, apoptosis, autophagy and intestinal Ca2+ absorption.
Results: The modulation of redox state, apoptosis and autophagy are mechanisms that are involved in the action of BAs on intestinal Ca2+ absorption. Although the mechanisms are still not completely understood, we provide the latest knowledge regarding the effect of BAs on intestinal Ca2+ absorption.
Conclusion: The response of the intestine to absorb Ca2+ is affected by BAs, but it is different according to the type and dose of BA. When there is a single administration, NaDOC has an inhibitory effect, UDCA is an stimulator whereas LCA does not have any influence. However, the combination of BAs modifies the response. Either UDCA or LCA protects the intestine against the oxidative injury caused by NaDOC by blocking the oxidative/nitrosative stress, apoptosis and autophagy.
Export Options
About this article
Cite this article as:
Molecular Mechanisms Triggered by Bile Acids on Intestinal Ca2+ Absorption, Current Medicinal Chemistry 2018; 25 (18) . https://dx.doi.org/10.2174/0929867324666171116125131
DOI https://dx.doi.org/10.2174/0929867324666171116125131 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Effects of the Capsular Polysaccharides of Cryptococcus neoformans on Phagocyte Migration and Inflammatory Mediators [General Articles]
Current Medicinal Chemistry Cell Death and Survival Through the Endoplasmic Reticulum- Mitochondrial Axis
Current Molecular Medicine Applications of Lentiviral Vectors for Biology and Gene Therapy of Neurological Disorders
Current Gene Therapy <i>Drosophila melanogaster</i> a Versatile Model of Parkinson’s Disease
CNS & Neurological Disorders - Drug Targets 4-Aminocyclopentane-1,3-diols as Platforms for Diversity: Synthesis of Anandamide Analogs
Medicinal Chemistry Preface [Hot Topic: Cannabinoid Receptors (Guest Editor: Maria L. Lopez-Rodriguez)]
Current Medicinal Chemistry - Central Nervous System Agents Phosphorylation-Dephosphorylation Imbalance of Cytoskeletal Associated Proteins in Neurodegenerative Diseases
Recent Patents on CNS Drug Discovery (Discontinued) Glucose Transporters in Sex Steroid Hormone Related Cancer
Current Vascular Pharmacology Obstructive Sleep Apnea and Type 2 Diabetes: Dual Interaction
Current Respiratory Medicine Reviews Editorial: Asleep at the Wheel: Concerning Driving after Co-Consumption of Alcohol and Benzodiazepines
Current Drug Abuse Reviews Natural Steroids and Androgen Antagonists used as Neuroprotection in Common Neurological Disorders
CNS & Neurological Disorders - Drug Targets Understanding Genetic Factors in Idiopathic Scoliosis, a Complex Disease of Childhood
Current Genomics Toward a Developmentally Centered Approach to Adolescent Alcohol and Substance Use Treatment
Current Drug Abuse Reviews Conformational Changes Induced by P32T Substitution in Human Phosphatase ITPA
Current Chemical Biology Therapeutic Strategies for Alzheimer's and Parkinson's Diseases by Means of Drug Delivery Systems
Current Medicinal Chemistry Computational Approaches to Screen Candidate Ligands with Anti- Parkinson’s Activity Using R Programming
Current Topics in Medicinal Chemistry Systems Biology Experimental Design - Considerations for Building Predictive Gene Regulatory Network Models for Prokaryotic Systems
Current Genomics Metal Transport and Homeostasis within the Human Body: Toxicity Associated with Transport Abnormalities
Current Medicinal Chemistry Melatonin Metabolism in the Central Nervous System
Current Neuropharmacology Pediatrics for Disability: A Comprehensive Approach to Children with Syndromic Psychomotor Delay
Current Pediatric Reviews