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Review Article

G4-相互作用的DNA解旋酶和聚合酶：潜在的治疗靶点

卷 26, 期 16, 2019

页: [2881 - 2897] 页: 17

弟呕挨: 10.2174/0929867324666171116123345

价格: $65

摘要

背景：富含鸟嘌呤的DNA可折叠成高度稳定的四链DNA结构，称为G-四链体（G4）。 近年来，G-quadruplex领域蓬勃发展，因为新的证据强烈表明这种交替折叠的DNA结构可能存在于体内。 G4 DNA为复制机制提供了障碍，并且真核DNA解旋酶和聚合酶已经进化为在体内分辨和复制G4 DNA。 此外，G4形成序列在基因启动子中普遍存在，表明G4-拆分解旋酶起调节转录的作用。 方法：我们搜索了PubMed数据库，以编制该领域当前知识的最新和全面评估，以概述Gquadruplexes与DNA解旋酶和聚合酶分子相互作用的分子相互作用。 结果：出现了新的计算工具和替代策略来检测G4形成序列并评估其生物学后果。 专门的DNA解旋酶和聚合酶催化作用于G4形成序列，以维持正常的复制和基因组稳定性以及适当的基因调节和细胞稳态。 G4解旋酶也解决端粒重复以维持染色体DNA末端。 通过反式DNS聚合酶或PrimPol DNA聚合酶的作用实现许多G4形成序列的旁路。 虽然集体工作支持G4在核DNA代谢中的作用，但新兴领域的核心是线粒体基因组中的G4丰度。 结论：发现特异性结合和调节DNA解旋酶和聚合酶或与G4 DNA结构本身相互作用的小分子可能对开发抗癌方案有用。

关键词: G-四链体，复制，解旋酶，聚合酶，翻译合成，G4 DNA，PrimPol。

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