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Review Article

舒尼替尼治疗甲状腺癌

卷 26, 期 6, 2019

页: [963 - 972] 页: 10

弟呕挨: 10.2174/0929867324666171006165942

价格: $65

摘要

背景：舒尼替尼（SU11248）是一种口服多靶点酪氨酸激酶抑制剂（TKI），具有低分子量，抑制血小板衍生生长因子受体（PDGF-Rs）和血管内皮生长因子受体（VEGFRs），c-KIT， fms相关酪氨酸激酶3（FLT3）和RET。这些途径的同时抑制减少肿瘤血管形成并引起癌细胞凋亡，诱导肿瘤缩小。舒尼替尼被批准用于治疗伊马替尼耐药的胃肠道间质瘤（GIST），肾癌和胰腺神经内分泌肿瘤。 方法：我们在PubMed库中搜索了文献。 结果：体外研究表明舒尼替尼靶向RET / PTC1细胞中的细胞溶质MEK / ERK和SAPK / JNK途径抑制细胞增殖并引起RET / PTC1细胞中钠/碘转运体（NIS）基因表达的刺激。此外，舒尼替尼在体外和体内对抗间变性甲状腺癌（ATC）细胞具有活性。大多数临床研究报道，舒尼替尼在晚期去分化甲状腺癌（DeTC）或甲状腺髓样癌（MTC）患者中作为一线和二线TKI治疗是有效的。舒尼替尼37.5毫克/天耐受性良好，有效。最常见的不良事件包括：血细胞计数减少（特别是白细胞），手足皮肤反应，腹泻，疲劳，恶心，高血压和肌肉骨骼疼痛。 结论：即使舒尼替尼在分化型甲状腺癌（DTC）治疗方面具有良好前景，但目前还没有发表过III期研究，为了评估舒尼替尼在侵袭性甲状腺癌中的实际疗效，还需要进行其他前瞻性研究。

关键词: 舒尼替尼，甲状腺，酪氨酸激酶，甲状腺未分化癌，甲状腺髓样癌，乳头状甲状腺癌，滤泡性甲状腺癌。

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