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Review Article

Virome和Inflammasomes，精细调整的平衡，对宿主健康有重要后果

卷 26, 期 6, 2019

页: [1027 - 1044] 页: 18

弟呕挨: 10.2174/0929867324666171005112921

价格: $65

摘要

背景：病毒体是通常栖息在人类中的病毒网络。它形成了所谓的微生物组的显着部分，一度被称为常驻菌群。事实上，感染人类而不会导致临床疾病的病毒越来越多地被认为是微生物组的一部分，并对我们的免疫系统的发展产生影响。此外，它们还能激活炎性体，多聚蛋白复合物，这些复合物在细胞中聚集并且负责感知病原体的下游效应。 目的：本综述旨在总结有关病毒体在调节炎症中的作用的证据，并强调Anelloviruses作为监测炎症过程和免疫系统能力的有用分子标记的证据。 方法：我们对过去5年发表的文献进行了综述，并对旧文献进行了总结，以考虑有关炎性体组装和病毒体的突破性发现。 结果：最近出现的大量数据表明微生物组密切反映了我们吃的东西以及许多其他意想不到的变量。微生物组的组成，位置和数量对先天和适应性免疫防御具有影响。构成病毒体的病毒有助于塑造免疫系统。这种病毒中最着名的Anelloviruses存在于大多数人类中，持续存在而不会引起明显的疾病。根据它们与这些病毒的相互作用，炎性体指导宿主防御能够耐受或丧失特定的微生物。 结论：病毒体在塑造人体免疫防御中起重要作用，并通过淬灭或增加它们来促进炎症过程。

关键词: 病毒体，微生物组，anelloviruses，扭矩teno病毒，炎症小体，先天免疫，toll样受体，pyroptosis。

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