Graphene Oxide Catalyzed C-N/C-S/[3+2] Cyclization Cascade for Green Synthesis of Thiazolidinone in Water

Title:Graphene Oxide Catalyzed C-N/C-S/[3+2] Cyclization Cascade for Green Synthesis of Thiazolidinone in Water

Volume: 15 Issue: 8

Author(s): Suhasini Mahata, Anjumala Sahu, Prashant Shukla, Ankita Rai, Manorama Singh and Vijai K. Rai*

Affiliation:

• Department of Chemistry, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh-495 009,India

Keywords: Graphene oxide, imine, mercaptoacetic acid, 1, 3-thiazolidin-4-one, water, organic.

Abstract: In this paper, first graphene oxide catalyzed one-pot three-component green synthesis of 1,3- thiazolidin-4-one using amine, aldehyde and mercapto acetic acid in water has been reported. The reaction is affected via sequential C-N and C-S bond formation and ring transformation reactions leading to thiazolidin-4-ones formation. The use of water as solvent at room temperature, good to excellent yields of pure products (75-92%) and operational simplicity are the salient features of the envisaged protocol. The graphene oxide catalyst is very mild, effective and most of its activity is preserved after being reused for five times.

Cite this article as:

Mahata Suhasini , Sahu Anjumala , Shukla Prashant , Rai Ankita , Singh Manorama and Rai K. Vijai *, Graphene Oxide Catalyzed C-N/C-S/[3+2] Cyclization Cascade for Green Synthesis of Thiazolidinone in Water, Letters in Organic Chemistry 2018; 15 (8) . https://dx.doi.org/10.2174/1570178614666171002145250