Title:Regenerative Medicine Applications in Wound Care
Volume: 12
Issue: 8
Author(s): Mohammad Ali Nilforoushzadeh, Mahsa Mollapour Sisakht*, Alexander Marcus Seifalian, Mohammad Amir Amirkhani, Hamid Reza Banafshe, Javad Verdi, Farzaneh Sharifzad and Ehsan Taghiabadi
Affiliation:
- Applied Cell Science Department, Kashan University of Medical Sciences and Skin and Stem Cell Research Center, Tehran University of Medical Sciences, P.O. Box: 13145- 784, Tehran,Iran
Keywords:
Regenerative medicine, cell therapy, wound, dermatology, skin, skin stem cell.
Abstract: Background: During the last two decades, a number of studies have been carried out on the
application of regenerative medicine in the field of dermatology.
Objective: The aim of this research was to critically review the application of regenerative medicine in
the field of dermatology. The next aim was to look in depth to see whether regenerative medicine
strategies have a place in the future of wound healing in a clinical setting. More specifically, to see if
these strategies would apply for burns and non-healing diabetic wounds.
Results: Billions of dollars have been spent worldwide on research in wound treatment and skin regeneration.
Although a high number of clinical trials show promising results, there is still no commercially
available treatment for use. In addition, the outcome data from the clinical trials, taking place throughout
the world, are not published in a standardized manner. Standardization within clinical trials is required
for: protocols, outcome, endpoint values, and length of follow-up. The lack of standardization
makes it much more difficult to compare the data collected and the different types of treatment.
Conclusion: Despite several promising results from research and early phase clinical studies, the treatment
for wounds as well as skin regeneration is still considered as an unmet clinical need. However, in
the past three years, more promising research has been approaching clinical trials; this could be the
solution that clinicians have been waiting for. This is a multibillion dollar industry for which there
should be enough incentive for researchers and industry to seek the solution.
