Title:Herbs for Effective Treatment of Diabetes Mellitus Wounds: Medicinal Chemistry and Future Therapeutic Options
Volume: 18
Issue: 8
Author(s): Farida Hussan, Mohamad Fairuz Yahaya, Seong Lin Teoh and Srijit Das*
Affiliation:
- Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur,Malaysia
Keywords:
Angiogenesis, diabetes mellitus, wound, healing, herb, macrophage, insulin.
Abstract: The incidence of diabetes mellitus (DM) has increased globally. Various complications such
as blindness, nephropathy leading to renal failure, neuropathy, foot ulceration, amputation, and disturbance
in autonomic nervous system were reported. Although, allopathy treatment still remains the
treatment of choice, there is a need to look at the easy availability, patient compliance and cheaper cost
of the drugs used in day-day practice. In this regard, complementary and alternative medicine has a
greater role to play. Numerous plant extracts were shown to exhibit antihyperglycemic properties. In
the present review, we surfed published literature in Pubmed and google databases with regard to the
herbs used for DM wound treatment. We also discuss the possible mechanism of wound healing in DM
with regard to advanced glycation end products, inflammation, macrophages, non-leukocytic cells such
as keratinocytes, fibroblasts and endothelial cells, matrix metalloproteinase and miRNA. The review
opens the door for effective treatment of DM wounds with plant extracts and plan future treatment options.