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Review Article

表观遗传调节因子作为癌症治疗学中可激活靶点的分子机制

卷 26, 期 8, 2019

页: [1328 - 1350] 页: 23

弟呕挨: 10.2174/0929867324666170921101947

价格: $65

摘要

表观遗传学定义为体细胞可遗传的变化，不伴随DNA序列的改变。表观遗传学包括DNA甲基化，共价组蛋白修饰，非编码RNA以及核小体重塑。值得注意的是，异常的表观遗传变化在癌症发展中起着关键作用，包括恶性转化，转移，预后，耐药性和肿瘤复发，这些都可以为癌症的预后，诊断和治疗提供有效的靶点。了解这些变化为癌症诊断提供了有效手段，并为更好的临床应用提供了药物治疗目标。近年来，已发现组蛋白修饰和相关酶与癌症发病率和预后良好相关。组蛋白修饰酶的失调表达或突变以及组蛋白修饰状态异常被认为在肿瘤发生和癌症治疗的临床结果中起重要作用。一些组蛋白修饰抑制剂已广泛用于临床实践中，并且许多其他抑制剂仍在实验室研究或临床前评估中。在这里，我们总结了表观遗传学的重要作用，特别是组蛋白修饰在癌症诊断和治疗方面的作用，并讨论了可激活的表观遗传靶标在癌症治疗学中的发展意义。

关键词: 癌症治疗学，表观遗传学，表观遗传调节剂，组蛋白修饰，组蛋白修饰，癌症治疗。

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