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Review Article

营养保健品和植物化学的“改变用途”药物预防和截取慢性退行性疾病和癌症

卷 26, 期 6, 2019

页: [973 - 987] 页: 15

弟呕挨: 10.2174/0929867324666170920144130

价格: $65

摘要

背景：慢性退行性疾病通常以炎症和异常血管生成为特征。对于这些病症，包括类风湿性关节炎，心血管和自身免疫疾病，癌症，糖尿病和肥胖，目前的疗法效果有限。 目标：迫切需要验证新的（化学）预防和拦截方法，以及单独或与注册药物联合使用新的或改变用途的药物。 结果：植物化学物质（三萜类化合物，类黄酮，类维生素A）及其衍生物，非甾体类抗炎药（阿司匹林）以及最初由植物化学骨架发育的双胍类（二甲双胍和苯乙双胍）是具有抗血管生成和抗炎症的多靶点药物。礼仪。其中许多靶向AMPK和代谢途径，例如mTOR轴。我们总结了几种化合物在赋予保护和支持疗法方面的有益作用，并且作为范例，我们提供了啤酒啤酒花中的萜类化合物和二萜类化合物以及来自橄榄油厂废水的羟基甾醇的数据。 结论：这些分子可用于癌症和其他慢性复杂疾病的组合化学预防和拦截方法或化学预防/治疗方案。

关键词: 营养保健品，植物化学药物，癌症，改变用途的药物，CD，异常血管生成。

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