摘要
背景:慢性肾脏疾病(CKD)仍然是公共卫生系统面临的重大挑战,它与用细胞外基质蛋白(如colo)替代肾功能组织相对应。泻湖和纤维连接蛋白。除肾保护策略外,目前还没有有效治疗CKD的方法。大麻素系统,更具体地说,大麻素受体1(CB1)和2(CB2)mAY是CKD治疗的新靶点。 方法:我们使用“大麻素受体”与“肾脏”、“肾病”、“糖尿病”、“肾纤维化”或“细胞途径”相结合的术语进行PubMed搜索。各种组合。我们分析了全文英语论文.。我们还查阅了已查明的文章的参考清单,以寻找进一步的相关文件。 结果:我们收集了正常肾生理和各种实验性肾病,尤其是糖尿病患者对大麻素系统的了解情况。我们还审查了在糖尿病和肥胖模型以及非代谢肾纤维化模型中,当使用CB1阻滞剂和/或CB2激动剂时获得的数据。我们还发现很少有数据可用,所以远距离细胞通路涉及大麻素受体下游在肾纤维化的发展过程中。 结论:大麻素受体在肾脏疾病和纤维化的发生发展中具有重要作用,尤其是CKD和糖尿病。
关键词: 大麻素受体,肾纤维化,糖尿病,慢性肾脏疾病,类内酰胺酶,肾生理学。
Current Medicinal Chemistry
Title:The Role of Cannabinoid Receptors in Renal Diseases
Volume: 25 Issue: 7
关键词: 大麻素受体,肾纤维化,糖尿病,慢性肾脏疾病,类内酰胺酶,肾生理学。
摘要: Background: Chronic kidney disease (CKD) remains a major challenge for Public Health systems and corresponds to the replacement of renal functional tissue by extra-cellular matrix proteins such as collagens and fibronectin. There is no efficient treatment to date for CKD except nephroprotective strategies. The cannabinoid system and more specifically the cannabinoid receptors 1 (CB1) and 2 (CB2) may represent a new therapeutic target in CKD.
Methods: We performed PubMed searches using the terms “cannabinoid receptors” in combination with “kidney” or ”renal disease” or “nephropathy” or “diabetes” or ”renal fibrosis” or ”cellular pathways” in various combinations. We analyzed full-text English-language papers. We also searched the reference lists of identified articles for further relevant papers.
Results: We gathered data regarding the current state of knowledge on the cannabinoid system in normal renal physiology and in various experimental nephropathies, especially diabetes. We also reviewed data obtained in models of diabetes and obesity as well as in non metabolic models of renal fibrosis when CB1 blockers and/or CB2 agonists were used. We also found that very few data are available so far regarding the cellular pathways involved downstream of the cannabinoid receptors in the development of renal fibrosis.
Conclusion: Overall, we found that the cannabinoid receptors are a promising target in the development of renal disease and fibrosis, particularly in CKD and diabetes.
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Cite this article as:
The Role of Cannabinoid Receptors in Renal Diseases, Current Medicinal Chemistry 2018; 25 (7) . https://dx.doi.org/10.2174/0929867324666170911170020
DOI https://dx.doi.org/10.2174/0929867324666170911170020 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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