Title:Proteins Commonly Linked to Autism Spectrum Disorder and Alzheimer's Disease
Volume: 19
Issue: 9
Author(s): Athanasios Alexiou*, Georgia Soursou, Nagendra Sastry Yarla and Ghulam Md Ashraf*
Affiliation:
- Novel Global Community Educational Foundation, Hebersham,Australia
- King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589,Saudi Arabia
Keywords:
Autism spectrum disorder, Alzheimer’s disease, proteins, developmental origins of health and diseases, neurological
symptoms.
Abstract: Several years after the first publication of Barker's Hypothesis the identification of common
patterns and pathways between genetic and epigenetic risk factors in neurodegenerative disorders is still
an open problem. For the cases of Alzheimer's disease and Autism and by taking into consideration the
increasing number of diagnosed cases globally, scientists focused on commonly expressed and related
proteins like Amyloid beta and the mechanisms of their underlying dysfunctionalities. In this review
paper, an attempt to specify significant correlations between proteins linked to Autism Spectrum Disorders
and Alzheimer’s Disease is presented. Both diseases are highlighted with an emphasis on the macromolecules
that play a fundamental role in their development. These proteins are described and analyzed
concerning the underlying pathology of these diseases.
