摘要
背景:近年来,从植物中提取的萘醌类化合物、体外培养物和半合成或全合成方法的研究都取得了新的进展。本文介绍了用毛状根培养法生产萘醌类化合物的方法,并对其最新的抗癌研究进展进行了综述。 目的:探讨毛状根培养中影响萘醌生产的生物技术策略。到目前为止,紫草素/烷基宁衍生物、犀牛皂甙和水飞蓟的主要来源是从植物材料中分离出来的,也是通过生物技术从植物中分离出来的。此外,还概述了在毛状根培养中产生的萘醌类化合物的最新抗癌活性研究。 方法:数据库调查采用两种选择标准:(1)在毛状根中可产生萘醌,(2)具有抗肿瘤作用。结果:综述了92篇文献,介绍了30种促进萘醌类化合物生产的生物技术途径,其中27种用于毛状根培养。 40篇论文概述了目标萘醌类化合物的抗癌活性,包括癌症类型和生物分析描述。综述了天然萘醌类化合物与其他抗癌药物的协同作用,并讨论了天然萘醌类化合物和植物提取物的毒性。该综述强调了毛状根调查的趋势,并指出了今后提高生物技术生产效率的可能研究方向。结论:毛状根培养在萘醌类化合物的生产中具有广阔的应用前景,可作为进一步开发的药物,特别是抗癌药物。这一领域的植物生物技术必将继续与传统和新的战略发展。
关键词: 毛状根,萘醌,细胞毒性,抗肿瘤活性,紫草素,水飞蓟酮,犀牛蛋白。
Current Medicinal Chemistry
Title:Hairy Root Cultures for the Production of Anti-cancer Naphthoquinone Compounds
Volume: 25 Issue: 36
关键词: 毛状根,萘醌,细胞毒性,抗肿瘤活性,紫草素,水飞蓟酮,犀牛蛋白。
摘要: Background: Recent years have brought the dynamic development in studies of naphthoquinones obtained from plants, in vitro cultures and semi- or total synthesis. This review presents the hairy root cultures approach for producing naphthoquinones and summarizes their most recent anti-cancer investigations.
Objective: This review aimed to define biotechnological strategies impacted on naphthoquinones production in hairy root cultures. Up to now the major source of shikonin/alkannin derivatives, rhinacanthins and ramentaceone is isolation from plant material, also derived via biotechnological methods. Moreover, the most recent anti-cancer activity studies on naphthoquinones which could be produced in hairy root cultures were outlined.
Methods: For databases survey two selection criteria were used: (i) naphthoquinone could be produced in hairy roots, and (ii) it exhibits anti-cancer properties.
Results: Ninety two papers were included in the review, thirty described biotechnological approaches enhancing naphthoquinones production, among them twenty seven were dedicated to hairy root cultures. Forty papers outlined the anti-cancer activity of targeted naphthoquinones including the type of cancer and bioassays description. The synergistic effect of natural naphthoquinones and other anti-cancer therapies was reviewed and toxicity of natural naphthoquinones and plant extracts was discussed. The review highlights tendencies in hairy root investigations and indicates the possible future research directions for improving biotechnological production efficacy.
Conclusion: This review demonstrates a great potential of hairy root cultures for naphthoquinones production, which could be furtherly developed for future medical purposes, especially as anti-cancer agents. This area of plant biotechnology will be surely still developed with traditional and new strategies.
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Hairy Root Cultures for the Production of Anti-cancer Naphthoquinone Compounds, Current Medicinal Chemistry 2018; 25 (36) . https://dx.doi.org/10.2174/0929867324666170821161844
DOI https://dx.doi.org/10.2174/0929867324666170821161844 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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