Title:Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma
Volume: 24
Issue: 9
Author(s): Carlos Alberto de Carvalho Fraga, Lucyana Conceicao Farias, Kimberly Marie Jones, Alfredo Mauricio Batista de Paula and Andre Luiz Sena Guimaraes*
Affiliation:
- Universidade Estadual de Montes Claros. Hospital Universitario Clemente Faria. Laboratorio de Pesquisa em Saude, 562 Av. Cula Mangabeira Santo Expedito. Montes Claros, MG,Brazil
Keywords:
Head and neck cancer, obesity, Angiogenesis, ACE, Ang 1-7, angiotensin-converting enzyme.
Abstract: Introduction: The Renin-Angiotensin System (RAS) has emerged as being related to
vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer.
Objective: This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting
enzymes (ACE and ACE2) as therapeutical targets for Malignant Epithelial Neoplasia,
specifically for Oral Squamous Cell Carcinoma (OSCC).
Conclusion: The literature review and Bioinformatics analyses showed that ACE and ACE2 are
interesting targets for OSCC treatment. Studies involving RAS and OSCC should be encouraged
for experimental validation.