[1]
Frantz S, Tillmanns J, Kuhlencordt PJ, et al. Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury. Am J Pathol 2007; 171(2): 507-12.
[2]
Blennow K, de Leon MJ, Zetterberg H. Alzheimer’s disease. Lancet 2006; 368(9533): 387-403.
[3]
Pratico D, Trojanowski JQ. Inflammatory hypotheses: Novel mechanisms of Alzheimer's neurodegeneration and new therapeutic targets? Neurobiol Aging 2000; 21(3): 441-5; 51-3.
[4]
Eckman EA, Eckman CB. Abeta-degrading enzymes: Modulators of Alzheimer’s disease pathogenesis and targets for therapeutic intervention. Biochem Soc Trans 2005; 33: 1101-5.
[5]
Nalivaeva NN, Fisk LR, Belyaev ND, Turner AJ. Amyloid-degrading enzymes as therapeutic targets in Alzheimer’s disease. Curr Alzheimer Res 2008; 5(2): 212-24.
[6]
Crews F, Nixon K, Kim D, et al. BHT blocks NF-kappaB activation and ethanol-induced brain damage. Alcohol Clin Exp Res 2006; 30(11): 1938-49.
[7]
Bourne KZ, Ferrari DC, Lange-Dohna C, Rossner S, Wood TG, Perez-Polo JR. Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides. J Neurosci Res 2007; 85(6): 1194-204.
[8]
Grilli M, Goffi F, Memo M, Spano P. Interleukin-1beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures. J Biol Chem 1996; 271(25): 15002-7.
[9]
Tak PP, Firestein GS. NF-kappaB: A key role in inflammatory diseases. J Clin Invest 2001; 107(1): 7-11.
[10]
Kaltschmidt B, Kaltschmidt C. NF-kappaB in the nervous system. Cold Spring Harbor Biol 2009; 1(3): a001271.
[11]
Yang L, Tao LY, Chen XP. Roles of NF-kappaB in central nervous system damage and repair. Neuroscience 2007; 23(5): 307-13.
[12]
Hwang CJ, Yun HM, Jung YY, et al. Reducing effect of IL-32alpha in the development of stroke through blocking of NF-kappaB, but enhancement of STAT3 pathways. Mol Neurobiol 2015; 51(2): 648-60.
[13]
Nijboer CH, Heijnen CJ, Groenendaal F, May MJ, van Bel F, Kavelaars A. Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines. Stroke 2008; 39(7): 2129-37.
[14]
Goodman Y, Mattson MP. Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity. J Neurochem 1996; 66(2): 869-72.
[15]
Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 1997; 49(6): 681-97.
[16]
Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D. NF-kappa B functions in synaptic signaling and behavior. Nat Neurosci 2003; 6(10): 1072-8.
[17]
O’Mahony A, Raber J, Montano M, et al. NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity. Mol Cell Biol 2006; 26(19): 7283-98.
[18]
Imielski Y, Schwamborn JC, Luningschror P, et al. Regrowing the adult brain: NF-kappaB controls functional circuit formation and tissue homeostasis in the dentate gyrus. PLoS One 2012; 7(2): e30838.
[19]
Barger SW, Horster D, Furukawa K, Goodman Y, Krieglstein J, Mattson MP. Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: Evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc Natl Acad Sci USA 1995; 92(20): 9328-32.
[20]
Bhakar AL, Tannis LL, Zeindler C, et al. Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Soc Neurosci 2002; 22(19): 8466-75.
[21]
Blondeau N, Widmann C, Lazdunski M, Heurteaux C. Activation of the nuclear factor-kappaB is a key event in brain tolerance. The Journal of neuroscience. J Soc Neurosci 2001; 21(13): 4668-77.
[22]
Kassed CA, Butler TL, Patton GW, et al. Injury-induced NF-kappaB activation in the hippocampus: Implications for neuronal survival. FASEB 2004; 18(6): 723-4.
[23]
Yu Z, Zhou D, Bruce-Keller AJ, Kindy MS, Mattson MP. Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury. J Neurosci 1999; 19(20): 8856-65.
[24]
Yu Z, Zhou D, Cheng G, Mattson MP. Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington’s disease. J Mol Neurosci 2000; 15(1): 31-44.
[25]
Sambamurti K, Kinsey R, Maloney B, Ge YW, Lahiri DK. Gene structure and organization of the human beta-secretase (BACE) promoter. FASEB 2004; 18(9): 1034-6.
[26]
Han Z, Boyle DL, Manning AM, Firestein GS. AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 1998; 28(4): 197-208.
[27]
Wang L, Zhang X, Liu L, et al. Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Brain Res 2010; 1321: 143-51.
[28]
Cui L, Zhang X, Yang R, et al. Baicalein is neuroprotective in rat MCAO model: Role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2. Pharmacol Biochem Behav 2010; 96(4): 469-75.
[29]
Liu Y, Zhang XJ, Yang CH, Fan HG. Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-kappaB expression. Brain Res 2009; 1268: 174-80.
[30]
Hunot S, Brugg B, Ricard D, et al. Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease. Proc Natl Acad Sci USA 1997; 94(14): 7531-6.
[31]
Chandel NS, Trzyna WC, McClintock DS, Schumacker PT. Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J Immunol 2000; 165(2): 1013-21.
[32]
Wu D, Cerutti C, Lopez-Ramirez MA, et al. Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-kappaB activation. J Int Soc Cereb Metabol 2015; 35(3): 412-23.
[33]
Peng X, Nie Y, Wu J, Huang Q, Cheng Y. Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-kappaB signaling pathway in high-fat diet rats. Biochem Biophys Res Commun 2015; 462(3): 245-50.
[34]
Li Y, Zhao L, Fu H, Wu Y, Wang T. Ulinastatin suppresses lipopolysaccharide induced neuro-inflammation through the downregulation of nuclear factor-kappaB in SD rat hippocampal astrocyte. Biochem Biophys Res Commun 2015; 458(4): 763-70.
[35]
Sung YH, Shin MS, Ko IG, et al. Ulinastatin suppresses lipopolysaccharide-induced prostaglandin E2 synthesis and nitric oxide production through the downregulation of nuclear factorkappaB in BV2 mouse microglial cells. Int J Mol Med 2013; 31(5): 1030-6.
[36]
Campbell SJ, Anthony DC, Oakley F, et al. Hepatic nuclear factor kappa B regulates neutrophil recruitment to the injured brain. J Neuropathol Exp Neurol 2008; 67(3): 223-30.
[37]
Mattson MP, Camandola S. NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest 2001; 107(3): 247-54.
[38]
Ridet JL, Malhotra SK, Privat A, Gage FH. Reactive astrocytes: Cellular and molecular cues to biological function. Trends Neurosci 1997; 20(12): 570-7.
[39]
Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci 2004; 24(9): 2143-55.
[40]
Liberto CM, Albrecht PJ, Herx LM, Yong VW, Levison SW. Pro-regenerative properties of cytokine-activated astrocytes. J Neurochem 2004; 89(5): 1092-100.
[41]
Farina C, Aloisi F, Meinl E. Astrocytes are active players in cerebral innate immunity. Trends Immunol 2007; 28(3): 138-45.
[42]
de Freitas MS, Spohr TC, Benedito AB, et al. Neurite outgrowth is impaired on HSP70-positive astrocytes through a mechanism that requires NF-kappaB activation. Brain Res 2002; 958(2): 359-70.
[43]
Schwaninger M, Sallmann S, Petersen N, et al. Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear factor-kappaB. J Neurochem 1999; 73(4): 1461-6.
[44]
Acarin L, Gonzalez B, Castellano B. Triflusal posttreatment inhibits glial nuclear factor-kappaB, downregulates the glial response, and is neuroprotective in an excitotoxic injury model in postnatal brain. Stroke 2001; 32(10): 2394-402.
[45]
Brambilla R, Bracchi-Ricard V, Hu WH, et al. Inhibition of astroglial nuclear factor kappa B reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med 2005; 202(1): 145-56.
[46]
Chen J, Zhou Y, Mueller-Steiner S, et al. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 2005; 280(48): 40364-74.
[47]
Jana M, Liu X, Koka S, Ghosh S, Petro TM, Pahan K. Ligation of CD40 stimulates the induction of nitric-oxide synthase in microglial cells. J Biol Chem 2001; 276(48): 44527-33.
[48]
Rasley A, Anguita J, Marriott I. Borrelia burgdorferi induces inflammatory mediator production by murine microglia. J Neuroimmunol 2002; 130(1-2): 22-31.
[49]
Moriyama N, Taniguchi M, Miyano K, Miyoshi M, Watanabe T. ANP inhibits LPS-induced stimulation of rat microglial cells by suppressing NF-kappaB and AP-1 activations. Biochem Biophys Res Commun 2006; 350(2): 322-8.
[50]
Matsuoka Y, Kitamura Y, Okazaki M, Terai K, Taniguchi T. Kainic acid-induced activation of nuclear factor-kappaB in rat hippocampus. Exp Brain Res 1999; 124(2): 215-22.
[51]
Acarin L, Gonzalez B, Castellano B. STAT3 and NFkappaB activation precedes glial reactivity in the excitotoxically injured young cortex but not in the corresponding distal thalamic nuclei. J Neuropathol Exp Neurol 2000; 59(2): 151-63.
[52]
Khasnavis S, Jana A, Roy A, et al. Suppression of nuclear factor-kappaB activation and inflammation in microglia by physically modified saline. J Biol Chem 2012; 287(35): 29529-42.
[53]
Heese K, Fiebich BL, Bauer J, Otten U. NF-kappaB modulates lipopolysaccharide-induced microglial nerve growth factor expression. Glia 1998; 22(4): 401-7.
[54]
Combs CK, Karlo JC, Kao SC, Landreth GE. Beta-Amyloid stimulation of microglia and monocytes results in TNF alpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 2001; 21(4): 1179-88.
[55]
Steinman L. Nuanced roles of cytokines in three major human brain disorders. J Clin Invest 2008; 118(11): 3557-63.
[56]
Griffin WS, Stanley LC, Ling C, et al. Brain interleukin 1 and S-100 immunoreactivity are elevated in down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 1989; 86(19): 7611-5.
[57]
Rahman SM, Van Dam AM, Schultzberg M, Crisby M. High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice. J Neuroimmunol 2005; 169(1-2): 59-67.
[58]
Sheng JG, Ito K, Skinner RD, et al. In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging 1996; 17(5): 761-6.
[59]
Lehmann ML, Brachman RA, Listwak SJ, Herkenham M. NF-kappaB activity affects learning in aversive tasks: Possible actions via modulation of the stress axis. Brain Behav Immun 2010; 24(6): 1008-17.
[60]
Hla T, Ristimaki A, Appleby S, Barriocanal JG. Cyclooxygenase gene expression in inflammation and angiogenesis. Ann N Y Acad Sci 1993; 696: 197-204.
[61]
Lee YJ, Choi IS, Park MH, et al. 4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway. Free Radic Biol Med 2011; 50(1): 66-77.
[62]
Li R, Yang L, Lindholm K, et al. Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death. J Neurosci 2004; 24(7): 1760-71.
[63]
Jin P, Kim JA, Choi DY, Lee YJ, Jung HS, Hong JT. Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer’s disease mice model. J Neuroinflammation 2013; 10: 2.
[64]
Lee YJ, Choi DY, Choi IS, et al. Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-beta generation and inflammatory reactions via inhibition of NF-kappaB and STAT3 activation in cultured astrocytes and microglial BV-2 cells. J Neuroinflammation 2011; 8: 132.
[65]
Ban JO, Oh JH, Kim TM, et al. Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfur compound isolated from garlic via inhibition of NF-kappaB. Art Ther 2009; 11(5): R145.
[66]
Choi IS, Lee YJ, Choi DY, et al. 4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-beta generation and accumulation in a mouse model of Alzheimer’s disease. J Alzheimers Dis 2011; 27(1): 127-41.
[67]
Kim JA, Yun HM, Jin P, et al. Inhibitory effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells. Neuropharmacology 2013; 79C: 476-87.
[68]
Lee JW, Lee YK, Ban JO, et al. Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice. J Nutr 2009; 139(10): 1987-93.
[69]
Lee YJ, Choi DY, Choi IS, et al. Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. J Neuroinflammation 2012; 9: 35.
[70]
Lee YK, Yuk DY, Lee JW, et al. (-)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency. Brain Res 2009; 1250: 164-74.
[71]
Lin GH, Lee YJ, Choi DY, et al. Anti-amyloidogenic effect of thiacremonone through anti-inflamation in vitro and in vivo models. J Alzheimers Dis 2012; 29(3): 659-76.
[72]
Terai K, Matsuo A, McGeer PL. Enhancement of immunoreactivity for NF-kappa B in the hippocampal formation and cerebral cortex of Alzheimer’s disease. Brain Res 1996; 735(1): 159-68.
[73]
Boissiere F, Hunot S, Faucheux B, et al. Nuclear translocation of NF-kappaB in cholinergic neurons of patients with Alzheimer’s disease. Neuroreport 1997; 8(13): 2849-52.
[74]
Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci USA 1997; 94(6): 2642-7.
[75]
Lukiw WJ, Bazan NG. Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer’s disease superior temporal lobe neocortex. J Neurosci Res 1998; 53(5): 583-92.
[76]
Hensley K. Neuroinflammation in Alzheimer’s disease: Mechanisms, pathologic consequences, and potential for therapeutic manipulation. J Alzheimers Dis 2010; 21(1): 1-14.
[77]
Choi DY, Lee JW, Lin G, et al. Obovatol attenuates LPS-induced memory impairments in mice via inhibition of NF-kappaB signaling pathway. Neurochem Int 2012; 60(1): 68-77.
[78]
Li YW, Zhang Y, Zhang L, et al. Protective effect of tea polyphenols on renal ischemia/reperfusion injury via suppressing the activation of TLR4/NF-kappaB p65 signal pathway. Gene 2014 25; 542(1): 46-51.
[79]
Shi JQ, Zhang CC, Sun XL, et al. Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-kappaB and NLRP3 inflammasome activation. CNS Neurosci Ther 2013; 19(4): 262-8.
[80]
Zhang X, Luhrs KJ, Ryff KA, Malik WT, Driscoll MJ, Culver B. Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice. Neuroscience 2009; 161(1): 53-8.
[81]
Echeverria V, Burgess S, Gamble-George J, et al. Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice. Neuroscience 2009; 162(4): 1220-31.
[82]
Wu J, Wang A, Min Z, et al. Lipoxin A4 inhibits the production of proinflammatory cytokines induced by beta-amyloid in vitro and in vivo. Biochem Biophys Res Commun 2011; 408(3): 382-7.
[83]
Gong QH, Pan LL, Liu XH, Wang Q, Huang H, Zhu YZ. S-propargyl-cysteine (ZYZ-802), a sulphur-containing amino acid, attenuates beta-amyloid-induced cognitive deficits and pro-inflammatory response: Involvement of ERK1/2 and NF-kappaB pathway in rats. Amino Acids 2011; 40(2): 601-10.
[84]
Gong QH, Wang Q, Pan LL, Liu XH, Xin H, Zhu YZ. S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-kappaB pathway in rats. Brain Behav Immun 2011; 25(1): 110-9.
[85]
Yu X, Wang LN, Du QM, et al. Akebia Saponin D attenuates amyloid beta-induced cognitive deficits and inflammatory response in rats: Involvement of Akt/NF-kappaB pathway. Behav Brain Res 2012; 235(2): 200-9.
[86]
Shishodia S, Amin HM, Lai R, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol 2005; 70(5): 700-13.
[87]
Natarajan K, Singh S, Burke TR Jr, Grunberger D, Aggarwal BB. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA 1996; 93(17): 9090-5.
[88]
Takada Y, Aggarwal BB. Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: Abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem 2004; 279(6): 4750-9.
[89]
Park YM, Won JH, Yun KJ, et al. Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclear factor-kappaB in RAW 264.7 cells. Biol Pharm Bull 2006; 29(5): 985-90.
[90]
Bae UJ. Lee da Y, Song MY, A prenylated flavan from Broussonetia kazinoki prevents cytokine-induced beta-cell death through suppression of nuclear factor-kappaB activity. Biol Pharm Bull 2011; 34(7): 1026-31.
[91]
Wang HM, Zhang T, Huang JK, Sun XJ. 3-N-butylphthalide (NBP) attenuates the amyloid-beta-induced inflammatory responses in cultured astrocytes via the nuclear factor-kappaB signaling pathway. Cell Physiol Biochem 2013; 32(1): 235-42.
[92]
Lee YY, Park JS, Jung JS, Kim DH, Kim HS. Anti-Inflammatory effect of ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells. Int J Mol Sci 2013; 14(5): 9820-33.
[93]
Kang CH, Jayasooriya RG, Dilshara MG, et al. Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-kappaB activation and ERK phosphorylation. Food Chem Toxicol 2012; 50(12): 4270-6.
[94]
Cheong MH, Lee SR, Yoo HS, et al. Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-kappa B activation in lipopolysaccharide-induced BV2 microglial cells. J Ethnopharmacol 2011; 137(3): 1402-8.
[95]
Lee da Y, Li H, Lim HJ, Lee HJ, Jeon R, Ryu JH. Anti-inflammatory activity of sulfur-containing compounds from garlic. J Med Food 2012; 15(11): 992-9.
[96]
Kwon HK, Hwang JS, So JS, et al. Cinnamon extract induces tumor cell death through inhibition of NF kappa B and AP1. BMC Cancer 2010; 10: 392.
[97]
Ghiso J, Frangione B. Amyloidosis and Alzheimer’s disease. Adv Drug Deliv Rev 2002; 54(12): 1539-51.
[98]
Selkoe DJ. Clearing the brain’s amyloid cobwebs. Neuron 2001; 32(2): 177-80.
