摘要
肌萎缩,或与年龄相关的肌肉衰退,发生在大多数生物体中,并负担人类健康和医疗保健系统。随着我们人口的老龄化,治疗肌萎缩的其他选择是必要的。线粒体功能障碍与肌细胞减少症的发生有关,因此应考虑针对改善肌肉线粒体功能的疗法。许多天然产生的化合物来源于一般食用的食物,具有抗肌萎缩作用,如天冬氨酸酰胺核苷、番茄红素和尿石蛋白A。这些天然产生的化合物可以通过调节线粒体的生物发生、细胞抗应力或有丝分裂来改善线粒体的健康和效率。进一步的研究应该评估改善线粒体健康的化合物是否能减轻人类的肌萎缩。
关键词: 肌萎缩,衰老,线粒体,有丝分裂,植物化学,烟酰胺腺嘌呤二核苷酸
Current Medicinal Chemistry
Title:Sarcopenia, Aging and Prospective Interventional Strategies
Volume: 25 Issue: 40
关键词: 肌萎缩,衰老,线粒体,有丝分裂,植物化学,烟酰胺腺嘌呤二核苷酸
摘要: Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.
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Sarcopenia, Aging and Prospective Interventional Strategies, Current Medicinal Chemistry 2018; 25 (40) . https://dx.doi.org/10.2174/0929867324666170801095850
DOI https://dx.doi.org/10.2174/0929867324666170801095850 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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