摘要
背景:2型糖尿病(T2DM)和癌症的发病率正在全世界范围内增加,使得这些疾病成为全球健康问题,同时医疗保健支出也在增加。目前治疗这些多种疾病的治疗方法远远不能令人满意。随着越来越多的证据显示褪黑激素(MLT)对2型糖尿病和癌症发生过程中发生的典型病理变化有益,本文综述了MLT的抗糖尿病和抗癌活性的分子方面,并且讨论了MLT研究的几个未来方向作为潜在的治疗剂应用。 方法:PubMed中心的重要文献分析结合个人专长。 结果:大量体外和体内研究表明,MLT通过减少高血糖,胰岛素抵抗,氧化应激和炎症通过调节不同的细胞内信号通路或参与了这一疾病的病理生理学其他目标拥有一批抗糖尿病健康的好处。越来越多的证据表明,MLT在多种人类恶性肿瘤中表现出多靶向的抗癌作用,主要是由于其调节与细胞存活,增殖和凋亡相关的几种信号转导途径的能力。此外,还观察到MLT与化疗和放疗有益的协同作用。重要的是,MLT的临床应用没有发现任何不良后果,其在癌症治疗中单独或与其他常规疗法联合强调了其治疗有用性。 结论:本综述中所述的研究结果表明,MLT可能为人类健康带来潜在的益处,特别是在T2DM和癌症方面。
关键词: 癌症,炎症,胰岛素抵抗,褪黑激素,氧化应激,2型糖尿病(T2DM)。
Current Medicinal Chemistry
Title:Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer
Volume: 24 Issue: 35
关键词: 癌症,炎症,胰岛素抵抗,褪黑激素,氧化应激,2型糖尿病(T2DM)。
摘要: Background: The incidence of both type 2 diabetes (T2DM) and cancer is increasing worldwide, making these diseases a global health problem along with increasing healthcare expenditures. The current therapeutic approaches for treating these multifactorial diseases are far from satisfactory. As increasing evidence shows beneficial effects of melatonin (MLT) on typical pathological changes occurring during the development of T2DM and cancer, the present review focuses on molecular aspects of antidiabetic and anticancer activities of MLT and, moreover, discusses several future directions of research regarding MLT application as potential therapeutic agent.
Methods: Critical literature analysis in PubMed central combined with personal expertise.
Results: Numerous in vitro and in vivo studies have revealed that MLT possesses a number of antidiabetic health benefits by diminishing hyperglycemia, insulin resistance, oxidative stress, and inflammation through modulating various intracellular signaling pathways or other targets involved in the pathophysiology of this disease. Mounting evidence also indicates that MLT exhibits multi-targeted anticancer effects in numerous human malignancies, mainly resulting from its ability to modulate several signal transduction pathways associated with cell survival, proliferation, and apoptosis. Furthermore, beneficial synergistic action of MLT with chemotherapy and radiotherapy has also been observed. Importantly, no adverse outcomes have been found from the clinical use of MLT, which highlights its therapeutic usefulness, either alone or in combination with other conventional therapies, in cancer treatment.
Conclusion: The findings described in this review suggest that MLT may confer potential benefits to human health, particularly in respect to T2DM and cancer.
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Cite this article as:
Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer, Current Medicinal Chemistry 2017; 24 (35) . https://dx.doi.org/10.2174/0929867324666170718110606
DOI https://dx.doi.org/10.2174/0929867324666170718110606 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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