摘要
熊果酸是一种天然的五环三萜,常见于具有良好生物学和药理活性的植物和食品中。 该化合物由于其通过低毒性的不同途径抑制肿瘤细胞的分化,血管生成,侵袭和转移而具有相当大的抗癌作用而受到研究人员的关注。 由于化合物在水中的溶解性差,熊果酸的生物利用度差。 熊果酸的低生物利用度和短血浆半衰期以及体内的非特异性分布被认为是化合物治疗开发中的障碍。 纳米药物递送系统可以改善一些药物的药代动力学,生物利用度和治疗活性。 本综述重点关注在癌症治疗中关于熊果酸的纳米药物递送系统的最新发展。
关键词: 生物利用度,癌症,纳米医学,天然化合物,熊果酸,综述。
Current Medicinal Chemistry
Title:Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery
Volume: 25 Issue: 37
关键词: 生物利用度,癌症,纳米医学,天然化合物,熊果酸,综述。
摘要: Ursolic acid, a natural pentacyclic triterpenoid is commonly found in plants and foods with promising biological and pharmacological activities. The compound has been under the attention of researchers due to its considerable anticancer effects through suppression of differentiation, angiogenesis, invasion, and metastasis of tumor cells via different pathways with low toxicity. Bioavailability of ursolic acid is poor due to poor solubility of the compound in water. Low bioavailability and short plasma half-life of ursolic acid along with non-specific distribution in the body are considered as impediments in the therapeutic development of the compound. Nano-drug delivery systems may improve the pharmacokinetic, bioavailability, and therapeutic activity of some medicines. The present review has focused on recent developments regarding nano-drug delivery systems of ursolic acid in cancer therapy.
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Cite this article as:
Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery, Current Medicinal Chemistry 2018; 25 (37) . https://dx.doi.org/10.2174/0929867324666170713102918
DOI https://dx.doi.org/10.2174/0929867324666170713102918 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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