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摘要
目前癌症治疗领域中最常见、最突出的是直接或间接的DNA损伤药物。直观的DNA不应该是相对非特异性小分子药物的一个完美目标。然而,目前的认识不是损伤细胞本身而是抗肿瘤药物对细胞DNA损伤的杀伤作用,与正常细胞相比,它们对癌细胞有特异性靶向作用。DNA损伤的化疗药物包括不同活性的化合物,即:直接或间接诱导DNA断裂,共价修饰DNA碱基,通过抑制染色质修饰酶改变染色质的结构和拓扑结构。本期题为《现代药物化学》……
Current Medicinal Chemistry
Title:Editorial: DNA Damage as a Strategy for Anticancer Chemotherapy
Volume: 24 Issue: 15
摘要: Amongst all currently used drugs in the field of cancer therapy, the most prominent group of agents which induce DNA, damage both directly or indirectly. Intuitively DNA should not be a perfect target for relatively unspecific small molecular weight drugs. However, the current understanding is that not damage per se but cellular response to DNA damage induced by antitumor agents is responsible for their specific targeted effect towards cancer cells in comparison to the normal cells. DNA damaging chemotherapeutics include compounds with diferent activities namely: directly or indirectly induce DNA strand breaks, covalently modify DNA bases, change the chromatin structure and topology by inhibiting chromatin-modifying enzymes. In this special issue of Current Medicinal Chemistry entitled....
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Cite this article as:
Editorial: DNA Damage as a Strategy for Anticancer Chemotherapy, Current Medicinal Chemistry 2017; 24 (15) . https://dx.doi.org/10.2174/092986732415170630115722
DOI https://dx.doi.org/10.2174/092986732415170630115722 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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