摘要
背景:本文综述了各种天然多酚在代谢功能障碍治疗中的作用。这些代谢异常包括胰岛素抵抗、游离脂肪酸水平升高、高胆固醇血症、肥胖、高血糖和高血压、糖尿病(DM)1型(T1DM)和2型糖尿病(T2DM)以及糖尿病引起的并发症。其中大多数都属于众所周知的代谢综合征(MS).这些代谢紊乱反过来又与心血管疾病的高风险密切相关。虽然代谢紊乱和相关并发症的发生的分子机制尚不清楚,但人们普遍认识到它们与氧化应激和慢性低级别炎症有关。方法:利用SciFinder对文献资料进行结构化检索。该数据库由ACS(美国化学学会)的一个部门提供,并保证访问世界上最广泛和最权威的参考资料来源。研究以血红素加氧酶-1为研究对象,并采用包容/排除标准对其进行细化。根据标准工具对检索到的论文质量进行评价。结果:从精选文献来看,使用天然抗氧化剂多酚似乎是理想的药理治疗方法,因为它们具有很强的抗氧化和抗炎作用。特别是姜黄素、槲皮素、染料木素和咖啡酸苯乙酯等多酚类物质能够有效地激活核因子红血球相关因子2(Nrf 2)和血红素加氧酶-1(HO-1)等相关酶的下游表达。事实上,HO-1的过度表达已经被证明在代谢疾病中起着有益的作用.结论:以下综述旨在激发人们对天然产生的HO-1诱导剂在代谢功能障碍中的作用的兴趣,重点探讨HO-1活性在恢复氧化和抗氧化系统平衡方面的临床潜力。
关键词: 多酚,氧化应激,糖尿病,纳什,NAFLD,代谢综合征,Nrf 2,HO-1。
Current Medicinal Chemistry
Title:Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions
Volume: 25 Issue: 13
关键词: 多酚,氧化应激,糖尿病,纳什,NAFLD,代谢综合征,Nrf 2,HO-1。
摘要: Background: The aim of this review is to summarize the effects of various naturally occurring polyphenols in the management of metabolic dysfunctions. This cluster of metabolic abnormalities comprises insulin resistance, increased levels of free fatty acids, hypercholesterolemia, obesity, hyperglycemia and hypertension, diabetes mellitus (DM) type 1 (T1DM) and type 2 (T2DM) along with DM-induced complications. Most of them are included in the well-known metabolic syndrome (MS). These metabolic dysfunctions in turn are tightly associated to a high risk of development of cardiovascular diseases. Although molecular mechanisms underlying the onset of metabolic dysfunctions and related complications are not yet clear, it is widely recognized that they are associated to oxidative stress and chronic low-grade of inflammatory levels.
Methods: We undertook a structured search of bibliographic references through the use of SciFinder. The database was provided by a division of ACS (American Chemical Society) and guarantees access to the world's most extensive and authoritative source of references. The search was performed using “heme oxygenase-1” as research topic and a subsequent refinement was done by using inclusion/exclusion criteria. The quality of retrieved papers was evaluated on the basis of standard tools.
Results: From a careful review of the selected literature, of interest, the use of natural antioxidant polyphenols seems to be the ideal pharmacological treatment since they are endowed with strong antioxidant and anti-inflammatory properties. In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1). Indeed, an overexpression of HO-1 has been demonstrated to play a beneficial role in metabolic diseases.
Conclusion: The following review is intended to stimulate interest in the role of natural occurring HO-1 inducers in metabolic dysfunction, focusing on the clinical potential of HO-1 activity to restore the balance between pro-oxidant and anti-oxidants systems.
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Cite this article as:
Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions, Current Medicinal Chemistry 2018; 25 (13) . https://dx.doi.org/10.2174/0929867324666170616110748
DOI https://dx.doi.org/10.2174/0929867324666170616110748 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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