Title:The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery
Volume: 13
Issue: 8
Author(s): Simone Q. Pantaleao, Drielli G.V. Fujii, Vinicius G. Maltarollo, Danielle da C. Silva, Gustavo H.G. Trossini, Karen C. Weber, Luis P.B. Scott and Kathia M. Honorio*
Affiliation:
- School of Arts, Sciences and Humanities, University of Sao Paulo, 03828-000, Sao Paulo, SP,Brazil
Keywords:
Biological targets, computational chemistry, diabetes, drug design, QSAR, virtual screening.
Abstract: Background: Due to the increasing number of diabetes cases worldwide, there is an international
concern to provide even more effective treatments to control this condition.
Methods: This review brings together a selection of studies that helped to broaden the comprehension
of various biological targets and associated mechanisms involved in type 2 diabetes mellitus.
Results: Such studies demonstrated that QSAR techniques and virtual screenings have been successfully
employed in drug design projects.
Conclusions: Therefore, the main goal of this review is to give the state-of-art for the development
of new drugs for the treatment of type 2 diabetes mellitus and to evaluate how computational
tools, such as virtual screening and 3D-QSAR, can aid the development of new drugs with reduced
adverse side effects.