Title:Multi-target Pharmacological Effects of Platycodin D
Volume: 14
Issue: 4
Author(s): Zhong-rong Zhang and Chun Wai Chan*
Affiliation:
- School of Chinese Medicine, Li Wai Chun Building, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong,China
Keywords:
Platycodin D, Platycodon grandiflorum, antioxidant, anti-inflammation, anticancer, anti-obesity, hepatoprotection.
Abstract: Plant secondary metabolites are considered as a valuable source to identify promising lead
compounds for developing novel drugs. Platycodin D is regarded as one of the major bioactive compounds
in medicinal plant Platycodon grandiflorum, which attracts researchers to study its therapeutic
effect recently. This paper reviews the latest research of biological and pharmacological activities of
platycodin D. In vitro and in vivo experimental evidences have revealed that platycodin D demonstrates
multiple pharmacological properties including anti-oxidative, anti-inflammatory, anticancer, antiobesity
and hepatoprotective effects. The underlying mechanisms of multiple therapeutic functions of
platycodin D are very likely associated with its anti-inflammatory and antioxidant nature, whereas low
bioavailability should be considered in drug development.
