Abstract
A majority of the world’s population continues to use traditional natural medicines based on the established knowledge of local plants for the treatment of various disease states. Often the same plant is recognized having several traditional uses. For the past few decades, the idea of "one drug, one activity, one disease" has dominated drug discovery in Western medicine, the so-called “magic bullet” approach. However, this view has been transformed through the discovery of the multi-targeting of bioactive compounds, which has opened up new areas for pharmaceutical development wherein the same drug may be simultaneously approved for the treatment of different diseases. Pursuing that discovery pathway, a wide variety of natural products have been evaluated for their multiple biological characteristics, such as analgesic, anti-proliferative, anti-inflammatory, anti-bacterial and anti-oxidant effects, among others. This mini-review highlights some of the recent findings concerning multi-target bioactive, plant-derived metabolites with a special emphasis on alkaloids and terpenoids. The alkaloids selected were colchicine, capsaicin, and vincristine, while the terpenoids chosen were artemisinin, taxol (paclitaxel), and masticadienonic acid. Issues relating to the sustainability of supply, and the efficiency of future drug discovery based on network pharmacology approaches are also mentioned.
Keywords: Multi-target bioactive natural compounds, alkaloids, terpenoids, anti-proliferative agents, anti-inflammatory activity, analgesic activity, sustainable medicines
Mini-Reviews in Organic Chemistry
Title:Multi-target Activities of Selected Alkaloids and Terpenoids
Volume: 14 Issue: 4
Author(s): Aida Rodriguez-Garcia, Samira Hosseini*, Sergio O. Martinez-Chapa and Geoffrey A. Cordell
Affiliation:
- School of Engineering and Sciences, Tecnologico de Monterrey, 2501, Monterrey,Mexico
Keywords: Multi-target bioactive natural compounds, alkaloids, terpenoids, anti-proliferative agents, anti-inflammatory activity, analgesic activity, sustainable medicines
Abstract: A majority of the world’s population continues to use traditional natural medicines based on the established knowledge of local plants for the treatment of various disease states. Often the same plant is recognized having several traditional uses. For the past few decades, the idea of "one drug, one activity, one disease" has dominated drug discovery in Western medicine, the so-called “magic bullet” approach. However, this view has been transformed through the discovery of the multi-targeting of bioactive compounds, which has opened up new areas for pharmaceutical development wherein the same drug may be simultaneously approved for the treatment of different diseases. Pursuing that discovery pathway, a wide variety of natural products have been evaluated for their multiple biological characteristics, such as analgesic, anti-proliferative, anti-inflammatory, anti-bacterial and anti-oxidant effects, among others. This mini-review highlights some of the recent findings concerning multi-target bioactive, plant-derived metabolites with a special emphasis on alkaloids and terpenoids. The alkaloids selected were colchicine, capsaicin, and vincristine, while the terpenoids chosen were artemisinin, taxol (paclitaxel), and masticadienonic acid. Issues relating to the sustainability of supply, and the efficiency of future drug discovery based on network pharmacology approaches are also mentioned.
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Cite this article as:
Rodriguez-Garcia Aida , Hosseini Samira *, Martinez-Chapa O. Sergio and Cordell A. Geoffrey , Multi-target Activities of Selected Alkaloids and Terpenoids, Mini-Reviews in Organic Chemistry 2017; 14 (4) . https://dx.doi.org/10.2174/1570193X14666170518151027
DOI https://dx.doi.org/10.2174/1570193X14666170518151027 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
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The scope of this topic encompasses the structure, mechanism of action, chemical synthesis, and biosynthesis of active alkaloids. Alkaloids, a class of nitrogen-containing organic compounds with alkaline properties, originate from a diverse array of sources. Many alkaloids exhibit significant biological activities and serve as key constituents in numerous medicinal plants. ...read more
Advancements in Synthesis of Bioactive Compounds
This thematic issue focuses on elucidating advanced synthetic strategies for bioactive compounds, with the primary objective of deepening understanding of the rational design and construction of target molecules. The exploration encompasses a diverse range of techniques, established name reactions, and cutting-edge synthetic methodologies. Specifically, the issue delves into the synthesis ...read more
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
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During a fire accident, carbon monoxide, carbon dioxide, sulfur dioxide, and other toxic and harmful gases are the main components of fire smoke but are also important factors causing fire casualties and damage to electronic equipment. Effective removal of carbon monoxide, carbon dioxide, sulfur dioxide, and other toxic and hazardous ...read more
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