Title:Oral Nano-Delivery Systems for Colon Targeting Therapy
Volume: 5
Issue: 2
Author(s): Tianxu Zhang, Guanyin Zhu, Boyao Lu and Qiang Peng*
Affiliation:
- State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041,China
Keywords:
Bioavailability, drug delivery, gastrointestinal tract, nano-formulations, nanoparticles, oral administration.
Abstract: Background: Targeting drug delivery is an attractive research area, as it enables localized
treatment, improves the efficacy of therapeutics and reduces systemic toxicity. Colon targeting delivery
is particularly beneficial to the treatment of colon diseases, such as inflammatory bowel disease
and colon cancer, due to the improved local drug concentrations. The traditional strategies for colon
targeting delivery include time-dependent and pH-dependent technologies, etc. In recent years,
nanotechnology has emerged as a novel and efficient tool for targeting drug delivery. After oral administration,
nano-based formulations are able to protect drug from the harsh gastrointestinal environment
and selectively increase the drug concentration at the disease site. Various orally administered
drug-loaded nano-systems for colon targeting delivery have been well documented and shown
great potentials in colon disease therapy.
Objective: In this work, we aim to provide a comprehensive understanding of the recent progress in
the area of colon targeting delivery in combination with introduction of the pathophysiological
changes of diseased colon sites and the obstacles for drug delivery.
