Title:Ethanolamine Metabolism in the Mammalian Gastrointestinal Tract: Mechanisms, Patterns, and Importance
Volume: 17
Issue: 2
关键词:
乙醇胺，胞苷磷酸乙醇胺途径，N-酰基乙醇胺，磷脂酰乙醇胺，磷脂酰胆碱，磷脂酰丝氨酸，EutR，EutVW，IPEC，炎症，鼠伤寒沙门氏菌，大肠杆菌，乙酰辅酶A，脂质生物合成，短链脂肪酸
摘要: Nutritional exchanges and cooperation between bacteria in the gastrointestinal
tract and the mammalian host play an important role in health and disease.
Ethanolamine is an essential dietary lipid nutrient for animals and is abundant in both
intestinal and bacterial cell membranes. Ethanolamine can be utilized by intestinal
eukaryotic cells via the cytidine phosphoethanolamine pathway for de novo synthesis of
phosphatidylethanolamine, and certain bacteria are able to catabolize it as a major
carbon and/or nitrogen source with the help of ethanolamine utilization proteins. In
addition, ethanolamine utilization dramatically affects lipid metabolism and short-chain
fatty acid biosynthesis. Ethanolamine metabolism plays a significant role in the renewal
and proliferation of intestinal cells and intestinal inflammation, and ethanolamine may be
a nutritional target to diagnose or treat diseases such as inflammatory bowel disease.
This review summarizes the mechanisms of ethanolamine metabolism in the mammalian
gastrointestinal tract and its influence on intestinal health and immunity, thus providing a
theoretical reference for further studies on mammalian nutrition and disease.
