摘要
Poly(ADP-核糖)聚合酶(PARP-1)是一种核酶在不同的细胞功能中起着关键的作用,如DNA损伤修复、转录调控和细胞死亡。此外,PARP-1已经出现在多种炎性疾病的发病机制的关键球员,已经成为心血管疾病治疗的一个新的目标,神经退行性e疾病与癌症。越来越多的证据与改变PARP-1的表达水平,多态性酶活性及消化道恶性肿瘤的存在,包括丁、食管、胃、胰腺、肝脏和结直肠癌。PARP抑制剂已被推荐为治疗这些胃肠疾病的一个有价值的战略。本文概述了MOS。不重要的现有文献对PARP-1在胃肠道肿瘤的介入,特别是其在肿瘤发生发展中的作用,提供信息C临床试验和探索治疗的可能性。
关键词: 生物标志物,肿瘤,胃肠道肿瘤,PARP抑制剂、多聚(ADP-核糖)聚合酶(PARP-1),合成致死。
Current Medicinal Chemistry
Title:Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement
Volume: 24 Issue: 20
关键词: 生物标志物,肿瘤,胃肠道肿瘤,PARP抑制剂、多聚(ADP-核糖)聚合酶(PARP-1),合成致死。
摘要: Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that plays a critical role in diverse cellular functions, such as DNA damage detection and repair, transcriptional regulation and cell death. Furthermore, PARP-1 has emerged as a key player in the pathogenesis of multiple inflammatory diseases and has become a promising target for the treatment of cardiovascular disorders, neurodegenerative diseases and cancer. An increasing body of evidence has linked alterations in the expression levels of PARP-1, enzymatic activity and presence of polymorphism to gastrointestinal malignancies, including oesophageal, gastric, pancreas, liver and colorectal cancers. PARP inhibition has been proposed as a valuable strategy for treating these gastrointestinal disorders. This paper summarises the most significant current literature on the involvement of PARP-1 in gastrointestinal cancer, focusing in particular on its role in the development and occurrence of tumours, providing information about clinical trials and exploring therapeutic possibilities.
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Cite this article as:
Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement, Current Medicinal Chemistry 2017; 24 (20) . https://dx.doi.org/10.2174/0929867324666170316115039
DOI https://dx.doi.org/10.2174/0929867324666170316115039 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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