摘要
吡咯并[2,3-d]嘧啶核是一个腺嘌呤脱氮等排,ATP的含氮碱基,而且在许多不同的激酶的ATP竞争性抑制剂。在过去的几年中麻木了涉及这种抑制剂的文章和专利的ER已经显著增加,一些化合物已被批准用于治疗炎症或骨髓增生性疾病。其他衍生物目前正在临床试验中评价。本文综述了吡咯并[2 ] - D作为激酶抑制剂的嘧啶衍生物,已在2011至2016年间的文献中报道,对最近获得专利的化合物特别感兴趣。分子根据被抑制的激酶分类,侧重于它们的化学成分。结构( structure的名词复数 )。
关键词: 吡咯并[ 2,3-d]嘧啶、激酶抑制剂、专利、抗癌剂、抗炎剂。
Current Medicinal Chemistry
Title:Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors
Volume: 24 Issue: 19
关键词: 吡咯并[ 2,3-d]嘧啶、激酶抑制剂、专利、抗癌剂、抗炎剂。
摘要: The pyrrolo[2,3-d]pyrimidine nucleus is a deaza-isostere of adenine, the nitrogenous base of ATP, and is present in many ATP-competitive inhibitors of different kinases. In the last few years the number of articles and patents that have appeared involving this type of inhibitors has dramatically increased and some compounds have been approved for the treatment of inflammatory or myeloproliferative diseases. Other derivatives are currently being evaluated in clinical trials. This review deals with pyrrolo[2,3- d]pyrimidine derivatives active as kinase inhibitors that have been reported in the literature from 2011 to 2016, with a particular interest on the recently patented compounds. The molecules are classified depending on the inhibited kinase, focusing on their chemical structures.
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Cite this article as:
Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors, Current Medicinal Chemistry 2017; 24 (19) . https://dx.doi.org/10.2174/0929867324666170303162100
DOI https://dx.doi.org/10.2174/0929867324666170303162100 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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