Title:Clinical Considerations of Focal Drug Delivery in Cancer Treatment
Volume: 14
Issue: 5
Author(s): Jamie Harris, Samuel C. Klonoski and Bill Chiu*
Affiliation:
- Department of Surgery, University of Illinois at Chicago, 840 S. Wood Street, Suite 416, Chicago, IL 60612,United States
Keywords:
Chemotherapy, local drug delivery, metastasis, radiation, resection, solid tumor.
Abstract: Background: According to the US Center for Disease Control, cancer deaths are the second
most common cause of mortality in both adults and children. Definitive treatment of solid tumors involves
surgical resection with or without systemic chemotherapy and radiation. The advent of local drug
delivery presents a unique treatment modality that can offer substantial benefits in cancer management.
Three main phases in solid tumor management exist for the treating physician: initial diagnosis with tissue
biopsy, surgical resection with or without chemotherapy, and management of metastatic disease.
Methods: A literature review of both basic science as well as clinical trials using local drug delivery
strategies in the management of solid tumors was done on PubMed. These were then further divided into
the categories of initial tissue biopsy intervention, surgical resection, and management of metastatic disease.
Results: A total of 27 articles were review that included both pre-clinical as well as clinical investigation
of local drug delivery therapies in the treatment of solid tumors. Treatments such as MRI guided
therapies, FDA approved local therapies for intracranial gliomas as well as local therapy for single site
metastatic disease were identified.
Conclusion: This review focuses the current state of local drug delivery in the treatment of solid tumors
in both the pre-clinical as well as clinical investigation settings. Local drug delivery therapy offers
an exciting new treatment modality for solid malignancies.
