Title:Approaches to Optimize Gene Therapy for the Treatment of Hematologic Malignancies: Overcoming the Obstacles
Volume: 16
Issue: 6
Author(s): Yingzhe Jiang, Bing Xia, Yizhuo Zhang*Wen Xu
Affiliation:
- Tianjin Medical University Cancer Institute and Hospital, 1 Huanhuxi Road, Hexi District, Tianjin 300060,China
Keywords:
Gene transfer, vaccination, RNAi, oncolytic viruses, hematologic malignancies.
Abstract: Gene transfer and oncolytic viruses provide new therapeutic approaches for the treatment of
hematologic malignancies. However, it is still too early to introduce gene delivery or oncolytic viruses
into standard clinical protocol. It is very important to discuss the obstacles that gene transfer and oncolytic
virotherapy face for the further clinical application for the treatment of hematologic malignancies,
and updating the advances made to overcome them. The major concerns in this review include the approaches
of the development of immuno-stimulatory gene transfer mediated-vaccination for leukemia
therapy, RNAi-based therapy for leukemia and enhancement of sensitivity of target malignant cells to
virotherapy and alteration of host immune response to favor oncolytic viruses. We conclude with a perspective
on the future of the gene therapy and virotherapy for the treatment of hematologic malignancies,
emphasizing the problems we should solve and the technological requirements for further clinical
applications.
