Title:Microwave-induced Triazole Synthesis via 1,3-dipolar azide-alkyne cycloaddition: Recent Advances
Volume: 3
Issue: 3
Author(s): Sujit Ghosh and Basudeb Basu*
Affiliation:
- Department of Chemistry, North Bengal University, Darjeeling 734 013,India
Keywords:
Azide-alkyne cycloaddition (AAC), microwave irradiation (MW), 1, 2, 3-triazole, regioisomer, copper catalyst,
metal-free, triazole synthesis.
Abstract: Background: 1,3-Dipolar azide-alkyne cycloaddition (AAC) reaction, often referred to
as click reaction, is an expeditious and robust protocol for the construction of triazole derivatives.
In most cases, the reaction is catalyzed by a copper catalyst.
Methods: Non-conventional microwave heating has been used for the reaction showing ample advantages
over the conventional thermal heating.
Conclusion: This article has presented an overview on the recent advances in the area of microwave-
induced AAC reactions in the presence of both homogeneous and heterogeneous copper
catalysts, besides a few examples of Ru-catalyzed as well as metal-free AAC reactions.
