Title:Identification of Sets of Cytoskeletal Related and Adhesion-related Coding Region Mutations in the TCGA Melanoma Dataset that Correlate with a Negative Outcome
Volume: 18
Issue: 3
Author(s): John M. Yavorski, Rebecca J. Stoll, Mohammad D. Samy, James A. Mauro and George Blanck*
Affiliation:
- Department of Molecular Medicine, Morsani College of Medicine, University of South Florida,United States
Keywords:
Cytoskeletal and cell-adhesion genomics, Cancer genome atlas, Extra-cellular matrix, Melanoma stratification,
Melanoma metastasis.
Abstract: Background: Relatively little cancer genome atlas data has been associated with clinically
relevant stratifications of individual cancers.
Results: Mutations in two subsets of a cytoskeletal related and adhesion-related protein coding region
set (CAPCRs) were determined to have strong associations with a negative outcome for melanoma,
including a subset constituted by: DSCAM, FAT3, MUC17 and PCDHGC5 (p < 0.0001).
Conclusion: Roles for CAPCR mutations in cancer progression raise a question about the potential
dominant negative impact of these mutations for multi-meric subcellular and extra-cellular protein
structures.
